The tumour–stroma ratio in colon cancer: the biological role and its prognostic impact

GW van Pelt, TP Sandberg, H Morreau… - …, 2018 - Wiley Online Library
The tumour microenvironment consists of a complex mixture of non‐neoplastic cells,
including fibroblasts, immune cells and endothelial cells embedded in the proteins of the …

The prognostic value of tumour–stroma ratio in primary breast cancer with special attention to triple-negative tumours: a review

CJH Kramer, KMH Vangangelt, GW Van Pelt… - Breast cancer research …, 2019 - Springer
Purpose There is a strong need to improve the prognostication of breast cancer patients in
order to prevent over-and undertreatment, especially when considering adjuvant …

Artificial intelligence quantified tumour-stroma ratio is an independent predictor for overall survival in resectable colorectal cancer

K Zhao, Z Li, S Yao, Y Wang, X Wu, Z Xu, L Wu… - …, 2020 - thelancet.com
Background An artificial intelligence method could accelerate the clinical implementation of
tumour-stroma ratio (TSR), which has prognostic relevance in colorectal cancer (CRC). We …

Deep learning in digital pathology for personalized treatment plans of cancer patients

Z Wen, S Wang, DM Yang, Y Xie, M Chen… - Seminars in diagnostic …, 2023 - Elsevier
Over the past decade, many new cancer treatments have been developed and made
available to patients. However, in most cases, these treatments only benefit a specific …

[HTML][HTML] How to measure tumour response in rectal cancer? An explanation of discrepancies and suggestions for improvement

ID Nagtegaal, R Glynne-Jones - Cancer treatment reviews, 2020 - Elsevier
Various methods categorize tumour response after neoadjuvant therapy, including down-
staging and tumour regression grading. Response categories allow comparison of different …

The prognostic value of the tumor–stroma ratio is most discriminative in patients with grade III or triple‐negative breast cancer

KMH Vangangelt, AR Green… - … journal of cancer, 2020 - Wiley Online Library
The tumor–stroma ratio (TSR) was evaluated as a promising parameter for breast cancer
prognostication in clinically relevant subgroups of patients. The TSR was assessed on …

Tumour stroma ratio is a potential predictor for 5-year disease-free survival in breast cancer

D Yan, X Ju, B Luo, F Guan, H He, H Yan, J Yuan - BMC cancer, 2022 - Springer
Background The tumour–stroma ratio (TSR) is identified as a promising prognostic
parameter for breast cancer, but the cutoff TSR value is mostly assessed by visual …

Significance of Tumor–Stroma Ratio (TSR) in Predicting Outcomes of Malignant Tumors

JS Pyo, NY Kim, KW Min, DW Kang - Medicina, 2023 - mdpi.com
Background and Objectives: The present study aimed to elucidate the distribution and the
prognostic implications of tumor–stroma ratio (TSR) in various malignant tumors through a …

The tumor-stroma ratio in giant cell tumor of bone: associations with the immune microenvironment and responsiveness to denosumab treatment

HL Wu, XB Wang, J Li, BW Zheng - Journal of Orthopaedic Surgery and …, 2024 - Springer
Background Currently, there is limited understanding regarding the clinical significance of
the tumor-stroma ratio (TSR) in giant cell tumor of bone (GCTB). Hence, we aimed to …

Increased RAB31 expression in cancer-associated fibroblasts promotes colon cancer progression through HGF-MET signaling

T Yang, H Zhiheng, W Zhanhuai, X Qian, L Yue… - Frontiers in …, 2020 - frontiersin.org
RAB family proteins participate in the dynamic regulation of cellular membrane
compartments and are dysregulated in a variety of tumor types, which may alter the …