Somatostatin, also known as somatotropin-release inhibitory factor, is a cyclopeptide that
exerts potent inhibitory actions on hormone secretion and neuronal excitability. Its …

Kisspeptin–GPR54 signaling in the hypothalamus is required for reproduction and fertility in
mammals. Kiss1 neurons are key regulators of gonadotropin-releasing hormone (GnRH) …

Neurons in the hypothalamic arcuate nucleus (ARC) that co-express kisspeptin, neurokinin
B and dynorphin (KNDy cells) are essential for mammalian reproduction as key regulators of …

The current model for the synchronization of GnRH neural activity driving GnRH and LH
pulses proposes that a set of arcuate (ARC) neurons that contain kisspeptin, neurokinin B …

Early work in ewes provided a wealth of information on the physiological regulation of
pulsatile gonadotropin-releasing hormone (GnRH) secretion by internal and external inputs …

Background Energy allocation between growth and reproduction determines puberty onset
and fertility. In mammals, peripheral hormones such as leptin, insulin and ghrelin signal …

Precocious male maturation causes reduced welfare and increased production costs in
Atlantic salmon (Salmo salar) aquaculture. The pituitary produces and releases follicle …

Abstract Kisspeptin/Neurokinin B/Dynorphin (KNDy) neurons of the arcuate nucleus (ARC)
play a key role in the regulation of fertility. The ability to detect features of KNDy neurons that …

Elevated and sustained estradiol concentrations cause a gonadotropin-releasing hormone
(GnRH) and luteinizing hormone (LH) surge that is necessary for ovulation. In sheep …

Recent evidence has implicated neurokinin B (NKB) signaling in the retrochiasmatic area
(RCh) of the ewe in the LH surge. To test this hypothesis, we first lesioned NK3R neurons in …