Voltage‐gated calcium channels (VGCC) are abundant in the central nervous system and
serve a broad spectrum of functions, either directly in cellular excitability or indirectly to …

Epileptic encephalopathies are generally considered to be functional disruptions in the
balance between neural excitation and inhibition. Excitatory and inhibitory voltage-gated ion …

Cyclin-dependent kinase-like (CDKL) family proteins are serine/threonine protein kinases
and is a specific branch of CMGC (including CDK, MAPK, GSK). Its name is due to the …

Summary Cyclin-dependent kinase-like 5 (CDKL5) deficiency disorder (CDD) is a
neurodevelopmental syndrome caused by mutations in the X-linked CDKL5 gene. The early …

Voltage-gated Ca2+ channels (VGCCs) are highly expressed throughout numerous
biological systems and play critical roles in synaptic transmission, cardiac excitation, and …

Developmental and epileptic encephalopathies are severe neurological conditions in
clinical practice, among which loss-of-function mutations in brain-enriched serine-threonine …

CDKL5 deficiency disorder (CDD) is a rare developmental and epileptic encephalopathy
resulting from variants in cyclin-dependent kinase-like 5 (CDKL5) that lead to impaired …

Epilepsy-Linked Kinase CDKL5 Phosphorylates Voltage-Gated Calcium Channel Cav2. 3,
Altering Inactivation Kinetics and Neuronal Excitability Sampedro-Castañeda M, Baltussen …

Episodic ataxia type 1 (EA1) is a rare, autosomal dominantly inherited neurological
movement disorder caused by mutations in the KCNA1 gene, which encodes the voltage …

The size of our pupils changes continuously in response to variations in ambient light levels
to regulate the amount of light that reaches the retina for optimizing vision. However, even …