Macrophages are crucial members of the innate immune response and important regulators.
The differentiation and activation of macrophages require the timely regulation of gene …

As an essential component of innate immunity, macrophages have multiple functions in both
inhibiting or promoting cell proliferation and tissue repair. Diversity and plasticity are …

Abstract Nrf2 (NF-E2-related factor-2) transcription factor regulates oxidative/xenobiotic
stress response and also represses inflammation. However, the mechanisms how Nrf2 …

Genes that drive the proliferation, survival, invasion and metastasis of malignant cells have
been identified for many human cancers,,–. Independent studies have identified cell death …

The human body contains several hundred cell types, all of which share the same genome.
In metazoans, much of the regulatory code that drives cell type-specific gene expression is …

The poor clinical outcome in pancreatic ductal adenocarcinoma (PDA) is attributed to
intrinsic chemoresistance and a growth-permissive tumor microenvironment. Conversion of …

In tissues, macrophages are exposed to metabolic, homeostatic and immunoregulatory
signals of local or systemic origin that influence their basal functions and responses to …

Circadian clocks are encoded by a transcription-translation feedback loop that aligns
energetic processes with the solar cycle. We show that genetic disruption of the clock …

In recent years, researchers have devoted much attention to the diverse roles of
macrophages and their contributions to tissue development, wound healing, and …

According to current models, once the cell has reached terminal differentiation, the enhancer
repertoire is completely established and maintained by cooperatively acting lineage-specific …