Molecular basis for exercise-induced fatigue: the importance of strictly controlled cellular Ca2+ handling
The contractile function of skeletal muscle declines during intense or prolonged physical
exercise, that is, fatigue develops. Skeletal muscle fibers fatigue acutely during highly …
exercise, that is, fatigue develops. Skeletal muscle fibers fatigue acutely during highly …
Skeletal muscle CaV1.1 channelopathies
BE Flucher - Pflügers Archiv-European Journal of Physiology, 2020 - Springer
Ca V 1.1 is specifically expressed in skeletal muscle where it functions as voltage sensor of
skeletal muscle excitation-contraction (EC) coupling independently of its functions as L-type …
skeletal muscle excitation-contraction (EC) coupling independently of its functions as L-type …
The Ca2+ influx through the mammalian skeletal muscle dihydropyridine receptor is irrelevant for muscle performance
A Dayal, K Schrötter, Y Pan, K Föhr, W Melzer… - Nature …, 2017 - nature.com
Skeletal muscle excitation–contraction (EC) coupling is initiated by sarcolemmal
depolarization, which is translated into a conformational change of the dihydropyridine …
depolarization, which is translated into a conformational change of the dihydropyridine …
Oxidative stress‐induced dysregulation of excitation–contraction coupling contributes to muscle weakness
R Qaisar, S Bhaskaran, P Premkumar… - Journal of cachexia …, 2018 - Wiley Online Library
Background We have previously shown that the deletion of the superoxide scavenger, CuZn
superoxide dismutase, in mice (Sod1−/− mice) results in increased oxidative stress and an …
superoxide dismutase, in mice (Sod1−/− mice) results in increased oxidative stress and an …
A chemical chaperone improves muscle function in mice with a RyR1 mutation
Mutations in the RYR1 gene cause severe myopathies. Mice with an I4895T mutation in the
type 1 ryanodine receptor/Ca2+ release channel (RyR1) display muscle weakness and …
type 1 ryanodine receptor/Ca2+ release channel (RyR1) display muscle weakness and …
Critical role of intracellular RyR1 calcium release channels in skeletal muscle function and disease
The skeletal muscle Ca2+ release channel, also known as ryanodine receptor type 1
(RyR1), is the largest ion channel protein known and is crucial for effective skeletal muscle …
(RyR1), is the largest ion channel protein known and is crucial for effective skeletal muscle …
The out-of-field dose in radiation therapy induces delayed tumorigenesis by senescence evasion
A rare but severe complication of curative-intent radiation therapy is the induction of second
primary cancers. These cancers preferentially develop not inside the planning target volume …
primary cancers. These cancers preferentially develop not inside the planning target volume …
Fibroblast growth factor 23 does not directly influence skeletal muscle cell proliferation and differentiation or ex vivo muscle contractility
KG Avin, JA Vallejo, NX Chen… - American Journal …, 2018 - journals.physiology.org
Skeletal muscle dysfunction accompanies the clinical disorders of chronic kidney disease
(CKD) and hereditary hypophosphatemic rickets. In both disorders, fibroblast growth factor …
(CKD) and hereditary hypophosphatemic rickets. In both disorders, fibroblast growth factor …
Restricting calcium currents is required for correct fiber type specification in skeletal muscle
Skeletal muscle excitation-contraction (EC) coupling is independent of calcium influx. In fact,
alternative splicing of the voltage-gated calcium channel CaV1. 1 actively suppresses …
alternative splicing of the voltage-gated calcium channel CaV1. 1 actively suppresses …
Two zebrafish cacna1s loss-of-function variants provide models of mild and severe CACNA1S-related myopathy
Y Endo, L Groom, SM Wang, E Pannia… - Human Molecular …, 2024 - academic.oup.com
CACNA1S-related myopathy, due to pathogenic variants in the CACNA1S gene, is a
recently described congenital muscle disease. Disease associated variants result in loss of …
recently described congenital muscle disease. Disease associated variants result in loss of …