Predicting COVID-19 booster immunogenicity against future SARS-CoV-2 variants and the benefits of vaccine updates

D Cromer, A Reynaldi, A Mitchell, TE Schlub… - Nature …, 2024 - nature.com
The ongoing evolution of the SARS-CoV-2 virus has led to a move to update vaccine
antigens in 2022 and 2023. These updated antigens were chosen and approved based …

Comparative effectiveness of bivalent (original/Omicron BA. 4/BA. 5) COVID-19 vaccines in adults

H Kopel, VH Nguyen, C Boileau, A Bogdanov, I Winer… - Vaccines, 2023 - mdpi.com
The emergence of Omicron variants coincided with declining vaccine-induced protection
against SARS-CoV-2. Two bivalent mRNA vaccines, mRNA-1273.222 (Moderna) and …

High SARS-CoV-2 antibody levels after three consecutive BNT162b2 booster vaccine doses in nursing home residents

MI Hofstee, J Kaczorowska, A Postema, E Zomer… - Immunity & …, 2025 - Springer
Background As older age and having certain comorbidities can influence humoral
responses to vaccination, we studied antibody responses after the COVID-19 booster …

Broad immunogenicity to prior SARS-CoV-2 strains and JN. 1 variant elicited by XBB. 1.5 vaccination in nursing home residents

Y Abul, C Nugent, I Vishnepolskiy, T Wallace… - GeroScience, 2024 - Springer
SARS-CoV-2 vaccination has reduced hospitalization and mortality for nursing home
residents (NHRs) but emerging variants and waning immunity challenge vaccine …

[HTML][HTML] Comparative Effectiveness of the Bivalent (Original/Omicron BA. 4/BA. 5) mRNA COVID-19 Vaccines mRNA-1273.222 and BNT162b2 Bivalent in Adults With …

H Kopel, VH Nguyen, A Bogdanov, I Winer, C Boileau… - Vaccines, 2024 - mdpi.com
Background/Objectives: This retrospective cohort study evaluated the relative vaccine
effectiveness (rVE) of two bivalent (original/Omicron BA. 4/BA. 5) vaccines mRNA-1273.222 …

Poor durability of the neutralizing response against XBB sublineages after a bivalent mRNA COVID‐19 booster dose in persons with HIV

G Matusali, A Vergori, E Cimini… - Journal of Medical …, 2024 - Wiley Online Library
We estimated the dynamics of the neutralizing response against XBB sublineages and T cell
response in persons with HIV (PWH) with previous AIDS and/or CD4< 200/mm3 receiving …

Neutralization and binding antibody response to second bivalent COVID-19 vaccination in nursing home residents

OA Oyebanji, Y Abul, BM Wilson, J Bosch, EM Didion… - 2023 - stacks.cdc.gov
To date, SARS-CoV-2 has infected more than 1.6 million US nursing home (NH) residents
and killed more than 160,000 1. Vaccination plays a vital role in preventing SARS-CoV-2 …

Antibody Responses to SARS-CoV-2 Vaccine in Nursing Home Residents Support a Bi-Annual Update Schedule

AN Paxitzis, OA Oyebanji, OJ Olagunju, D Keresztesy… - medRxiv, 2025 - medrxiv.org
Background: The COVID-19 pandemic has greatly affected nursing home residents (NHRs),
a vulnerable group with high rates of illness and death. While vaccination is essential for …

[PDF][PDF] Neutralization and binding antibody response to second bivalent COVID-19 vaccination in nursing home residents

Y Abul, AN Paxitzis, N Sundheimer, V Ragavapuram… - 2023 - researchgate.net
To date, SARS-CoV-2 has infected more than 1.6 million US nursing home (NH) residents
and killed more than 160,000. 1 Vaccination plays a vital role in preventing SARS-CoV-2 …

[PDF][PDF] The Global Burden of Infectious Respiratory Diseases in Adults: Interview with Three Key Opinion Leaders

A Chatterjee, S Gravenstein, T Schwarz - emjreviews.com
According to the WHO, the proportion of the world's population aged over 60 years will
almost double, from 12% to 22%, between 2015–2050. 1 This statistic underscores the need …