P16INK4A (also known as P16 and MTS1), a protein consisting exclusively of four ankyrin
repeats, is recognized as a tumor suppressor mainly because of the prevalence of genetic …

Cutaneous malignant melanoma (CMM) is the most life-threatening neoplasm of the skin
and is considered a major health problem as both incidence and mortality rates continue to …

Defects in epigenetic regulation play a fundamental role in the development of cancer, and
epigenetic regulators have recently emerged as promising therapeutic candidates. We …

Background Nucleosome translocation along DNA is catalyzed by eukaryotic SNF2-type
ATPases. One class of SNF2-ATPases is distinguished by the presence of a C-terminal …

Mutations or deletions in the cyclin-dependent kinase inhibitor p16 INK4A are associated
with multiple cancer types, but are more commonly found in melanoma tumors and …

Histone acetylation marks have an important role in controlling gene expression and are
removed by histone deacetylases (HDACs). These marks are read by bromodomain and …

Recent findings provide evidence for a functional interplay between DNA replication and the
seemingly distinct areas of cancer, development and pluripotency. Protein complexes …

The microphthalmia-associated transcription factor (MITF) promotes melanocyte
differentiation and cell-cycle arrest. Paradoxically, MITF also promotes melanoma survival …

Introduction: Cancer genome sequencing studies have discovered mutations in members of
the SWItch/Sucrose Non-Fermentable (SWI/SNF) chromatin-remodeling complex in nearly …

Abstract Epithelial–mesenchymal transition (EMT), a pivotal event during cancer
progression such as relapse and metastasis, is positively correlated with the stemness …