Ketamine has emerged as a transformative and mechanistically novel pharmacotherapy for
depression. Its rapid onset of action, efficacy for treatment-resistant symptoms, and …

Homeostatic synaptic plasticity is a negative feedback mechanism that neurons use to offset
excessive excitation or inhibition by adjusting their synaptic strengths. Recent findings …

WINNER OF THE 2014 BRAIN PRIZE From the acclaimed author of Reading in the Brain
and How We Learn, a breathtaking look at the new science that can track consciousness …

Typical therapies try to reverse pathogenic mechanisms. Here, we describe treatment effects
achieved by enhancing depression-causing mechanisms in ventral tegmental area (VTA) …

Recent advances in our understanding of the underlying genetic architecture of psychiatric
disorders has blown away the diagnostic boundaries that are defined by currently used …

The brain is astonishing in its complexity and capacity for change. This has fascinated
scientists for more than a century, filling the pages of this journal for the past 25 years. But a …

It is well established that the active properties of nerve and muscle cells are stabilized by
homeostatic signaling systems. In organisms ranging from Drosophila to humans, neurons …

Chemical synapses are sites of contact and information transfer between a neuron and its
partner cell. Each synapse is a specialized junction, where the presynaptic cell assembles …

Brain development, sensory information processing, and learning and memory processes
depend on Hebbian forms of synaptic plasticity, and on the remodeling and pruning of …

Homeostatic processes have been proposed to explain the discrepancy between the
dynamics of synaptic plasticity and the stability of brain function. Forms of synaptic plasticity …