The vertebrate retina is a clearly organized signal-processing system. It contains more than
60 different types of neurons, arranged in three distinct neural layers. Each cell type is …

Degeneration of photoreceptors in the retina is a leading cause of blindness, but commonly
leaves the retinal ganglion cells (RGCs) and/or bipolar cells extant. Consequently, these …

Hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channels are expressed in
several tissues throughout the body, including the heart, the CNS, and the retina. HCN …

Recent works suggest that one of the roles of gap junctions in sensory systems is to
enhance their dynamic range by avoiding early saturation in the first processing stages. In …

Objective. A major reason for poor visual outcomes provided by existing retinal prostheses is
the limited knowledge of the impact of photoreceptor loss on retinal remodelling and its …

Pathogenic variants in HCN1 are associated with a range of epilepsy syndromes including a
developmental and epileptic encephalopathy. The recurrent de novo HCN1 pathogenic …

Due to the ubiquity of spiking neurons in neuronal processes, various simple spiking neuron
models have been proposed as an alternative to conductance-based models (aka Hodgkin …

摘要生物神经系统是由数量极其巨大的神经元相互联结的信息网络系统, 在生物体的感觉,
认知和运动控制中发挥关键性的作用首先介绍神经兀, 大脑和一些生物神经网络的生理结构和 …

Introduction Current brain-based visual prostheses pose significant challenges impeding
adoption such as the necessarily complex surgeries and occurrence of more substantial …

Retinal degenerative diseases, such as retinitis pigmentosa, are generally thought to initiate
with the loss of photoreceptors, though recent work suggests that plasticity and remodeling …