Our understanding of diabetes mellitus has benefited from a combination of clinical
investigations and work in model organisms and cell lines. Organoid models for a wide …

Pleurotus spp. was one of the most precious and common edible fungi, polysaccharides
were the main active component. The structural, biological activities and structure-activity …

Glucokinase (GCK), a key enzyme in glucose metabolism, plays a central role in glucose
sensing and insulin secretion in pancreatic β-cells, as well as glycogen synthesis in the liver …

Stem cell-derived islets (SC-islets) offer the potential to be an unlimited source of cells for
disease modeling and the treatment of diabetes. SC-islets can be genetically modified …

The molecular link between SARS‐CoV‐2 infection and susceptibility is not well understood.
Nonetheless, a bi‐directional relationship between SARS‐CoV‐2 and diabetes has been …

FOXA2 has been identified as an essential factor for pancreas development and emerging
evidence supports an association between FOXA2 and diabetes. Although the role of …

Recent studies reported that pancreatic β-cells are heterogeneous in terms of their
transcriptional profiles and their abilities for insulin secretion. Sub-populations of pancreatic …

Non-obese diabetes (NOD) mice are an established, spontaneous model of type 1 diabetes
in which diabetes develops through insulitis. Using next-generation sequencing, coupled …

Mitochondrial diseases disrupt cellular energy production and are among the most complex
group of inherited genetic disorders. Affecting approximately 1 in 5000 live births, they are …

The study of diabetes mellitus (DM) patterns illustrates increasingly important facts. Most
importantly, they include oxidative stress, inflammation, and cellular death. Up to now, there …