Biological evaluation and in silico study of benzohydrazide derivatives as paraoxonase 1 inhibitors
IN Korkmaz, C Türkeş, Y Demir… - … of Biochemical and …, 2022 - Wiley Online Library
Abstract Serum paraoxonase 1 (PON1) is found in all mammalian species and is a calcium‐
dependent hydrolytic enzyme. PON1 hydrolyze several substrates, including carbonates …
dependent hydrolytic enzyme. PON1 hydrolyze several substrates, including carbonates …
A potential risk factor for paraoxonase 1: in silico and in-vitro analysis of the biological activity of proton-pump inhibitors
C Türkeş - Journal of Pharmacy and Pharmacology, 2019 - academic.oup.com
Abstract Objectives Proton-pump inhibitors (PPIs) are drugs commonly utilized by about 7%
of adults in the world. Recent researches have shown that there are countless and severe …
of adults in the world. Recent researches have shown that there are countless and severe …
Benzenesulfonamide derivatives containing imine and amine groups: Inhibition on human paraoxonase and molecular docking studies
Sulfonamides known as inhibitors of many metabolic enzymes have been widely used as
antimicrobial drugs for a long time. In the present study, we investigated in vitro inhibitory …
antimicrobial drugs for a long time. In the present study, we investigated in vitro inhibitory …
Synthesis and biological evaluation of phloroglucinol derivatives possessing α‐glycosidase, acetylcholinesterase, butyrylcholinesterase, carbonic anhydrase …
A series of novel phloroglucinol derivatives were designed, synthesized, characterized
spectroscopically and tested for their inhibitory activity against selected metabolic enzymes …
spectroscopically and tested for their inhibitory activity against selected metabolic enzymes …
Investigation of potential paraoxonase-I inhibitors by kinetic and molecular docking studies: chemotherapeutic drugs
C Türkeş - Protein and peptide letters, 2019 - ingentaconnect.com
Background: Metabolic processes in living organisms are closely related to the catalytic
activity of enzymes. Changes in enzyme activity cause various diseases eg, neurological …
activity of enzymes. Changes in enzyme activity cause various diseases eg, neurological …
Methyl benzoate derivatives: in vitro Paraoxonase 1 inhibition and in silico studies
IN Korkmaz, C Türkeş, Y Demir… - … of Biochemical and …, 2022 - Wiley Online Library
Abstract Paraoxonase 1 (PON1) can metabolize some compounds such as aromatic
carboxylic acid and unsaturated aliphatic esters, arylesters, cyclic carbonate, plucuronide …
carboxylic acid and unsaturated aliphatic esters, arylesters, cyclic carbonate, plucuronide …
Inhibition of human serum paraoxonase-I with antimycotic drugs: in vitro and in silico studies
C Türkeş, Ş Beydemir - Applied Biochemistry and Biotechnology, 2020 - Springer
Drugs show their pharmacological effects by inhibiting or activating enzymes. Therefore,
enzyme inhibitors have an essential place in the drug design for numerous different sorts of …
enzyme inhibitors have an essential place in the drug design for numerous different sorts of …
The inhibition effects of some sulfonamides on human serum paraoxonase-1 (hPON1)
Y Demir, Z Köksal - Pharmacological reports, 2019 - Springer
Abstract Background Paraoxonase 1 (PON1) is an antiatherogenic and organophosphate
hydrolyzer enzyme. It has important roles including protecting low density lipoprotein (LDL) …
hydrolyzer enzyme. It has important roles including protecting low density lipoprotein (LDL) …
In vitro and in silico studies on the toxic effects of antibacterial drugs as human serum paraoxonase 1 inhibitor
C Türkeş, Ş Beydemir, Öİ Küfrevioğlu - ChemistrySelect, 2019 - Wiley Online Library
The core purpose of the current study was to investigate the interactions of widely used
broad‐spectrum antibacterial drugs developed in response to the increasing rate of …
broad‐spectrum antibacterial drugs developed in response to the increasing rate of …
Some indazoles reduced the activity of human serum paraoxonase 1, an antioxidant enzyme: in vitro inhibition and molecular modeling studies
Abstract Background: Paraoxonase 1 (PON1: EC 3.1. 8.1) is a vital antioxidant enzyme
against mainly atherosclerosis and many other diseases associated with oxidative stress …
against mainly atherosclerosis and many other diseases associated with oxidative stress …