The nicotinic acetylcholine (ACh) receptor, at the neuromuscular junction, is a
neurotransmitter-gated ion channel that has been fine-tuned through evolution to transduce …

The ligand binding domain (LBD) of the nicotinic acetylcholine receptor has served as a
prototype for understanding molecular recognition in the family of neurotransmitter‐gated …

1. Excitatory postsynaptic currents (EPSCs) were recorded in CA3 pyramidal cells of
hippocampal slices of 15‐to 24‐day‐old rats (22 degrees C) using the whole‐cell …

The structure of the open-channel form of the acetylcholine receptor has been determined
from electron images of Torpedo ray postsynaptic membranes activated by brief (< 5ms) …

Objective: To determine the rate of functional decline in a large cohort of patients with
Huntington's disease (HD) followed at 43 sites by the Huntington Study Group (HSG) …

The nicotinic acetylcholine (ACh) receptor converts transiently to an open-channel form
when activated by ACh released into the synaptic cleft. We describe here the conformational …

ATP-gated P2X receptors in nociceptive sensory neurons participate in transmission of pain
signals from the periphery to the spinal cord. To determine the role of P2X receptors under …

We have examined CABA* receptor activation by making rapid applications of GABA to
outside-out patches excised from cultured postnatal rat cerebellar neurons. The rate of …

1. Activation and desensitization of N‐methyl‐D‐aspartate (NMDA) receptors were studied
in large outside‐out patches excised from cultured embryonic neurones dissociated from …

The rate constants of acetylcholine receptor channels (AChR) desensitization and recovery
were estimated from the durations and frequencies of clusters of single-channel currents …