Over the past decade, evidences of an integration of metabolic and inflammatory pathways,
referred to as metaflammation in several aspects of metabolic syndrome, have been …

n-3 and n-6 polyunsaturated fatty acids (PUFAs) are essential fatty acids that are provided
by dietary intake. Growing evidence suggests that n-3 and n-6 PUFAs are paramount for …

Normal placental development and proper angiogenesis are essential for fetal growth
during pregnancy. Angiogenesis involves the regulatory action of many angiogenic factors …

Fatty acid-binding protein-4 (FABP4), commonly known as adipocyte-fatty acid-binding
protein (A-FABP), is a pleiotropic adipokine that broadly affects immunity and metabolism. It …

Intrauterine hypoxia is a feature of pregnancy complications, both at high altitude and sea
level. To understand the placental response to reduced oxygen availability, small animal …

The prevalence of obesity and type 2 (T2D) diabetes is a major health concern in the United
States and around the world. T2D is a complex disease characterized by pancreatic β-cell …

Mechanistic Target of Rapamycin Complex 1 (mTORC1) serves as positive regulator of
placental nutrient transport and mitochondrial respiration. The role of mTORC1 signaling in …

Fatty acid-binding protein 4 (FABP4) participates in fatty-acid transportation and variation in
the gene has been reported to affect fat deposition in mammals. To assess the effects of …

Aims Fatty acid-binding protein 4 (FABP4) is mainly expressed in adipocytes and
macrophages and is demonstrated to be elevated in diabetes patients. The aim of this study …

Obesity in pregnancy is associated with increased fetal growth and adiposity, which, in part,
is determined by transplacental nutrient supply. Trophoblast uptake and intracellular …