Klinefelter syndrome, insulin resistance, metabolic syndrome, and diabetes: review of literature and clinical perspectives

A Salzano, R D'Assante, LM Heaney, F Monaco… - Endocrine, 2018 - Springer
Purpose Klinefelter syndrome (KS), the most frequent chromosomic abnormality in males, is
associated with hypergonadotropic hypogonadism and an increased risk of cardiovascular …

Metformin: up to date

S Sciannimanico, F Grimaldi, F Vescini… - … Metabolic & Immune …, 2020 - ingentaconnect.com
Background: Metformin is an oral hypoglycemic agent extensively used as first-line therapy
for type 2 diabetes. It improves hyperglycemia by suppressing hepatic glucose production …

Growth hormone deficiency is associated with worse cardiac function, physical performance, and outcome in chronic heart failure: insights from the TOS CA. GHD …

M Arcopinto, A Salzano, F Giallauria, E Bossone… - PLoS …, 2017 - journals.plos.org
Background Although mounting evidence supports the concept that growth hormone (GH)
deficiency (GHD) affects cardiovascular function, no study has systematically investigated its …

Multiple hormonal and metabolic deficiency syndrome in chronic heart failure: rationale, design, and demographic characteristics of the TOS CA. Registry

E Bossone, M Arcopinto, M Iacoviello… - Internal and Emergency …, 2018 - Springer
Recent evidence supports the concept that progression of chronic heart failure (CHF)
depends upon an imbalance of catabolic forces over the anabolic drive. In this regard …

Multiple hormone deficiency syndrome in heart failure with preserved ejection fraction

A Salzano, AM Marra, F Ferrara… - International …, 2016 - internationaljournalofcardiology.com
The heart failure (HF) epidemic, its ominous prognosis (worse than that of many cancers),
and the huge direct and indirect costs for health systems worldwide prompt the quest for …

Gender-related differences in pulmonary arterial hypertension targeted drugs administration

AM Marra, N Benjamin, C Eichstaedt, A Salzano… - Pharmacological …, 2016 - Elsevier
During the last 15 years, a real “paradigm-shift” occurred, due to the development of PAH-
targeted drugs, leading to crucial improvements in symptoms, exercise capacity …

Biomarkers in heart failure: clinical insights

A Salzano, R D'Assante, MZ Israr… - Heart Failure …, 2021 - heartfailure.theclinics.com
Heart failure (HF) is a clinical syndrome caused by structural and/or functional cardiac
abnormalities and resulting from impaired cardiac output or an increase of intracardiac …

Growth hormone therapy in heart failure

A Salzano, AM Marra, R D'Assante… - Heart failure …, 2018 - heartfailure.theclinics.com
Despite considerable improvement in the management of heart failure (HF), unsustainable
levels of morbidity and mortality coupled with an increasing economic and social burden …

Endocrinology of the stress response during critical illness

PE Marik - Critical care nephrology, 2019 - Elsevier
The stress system receives and integrates diverse cognitive, emotional, neurosensory, and
peripheral somatic signals that arrive through distinct pathways. Activation of the stress …

Vasopressin in heart failure

M Iovino, M Iacoviello, G De Pergola… - … Metabolic & Immune …, 2018 - ingentaconnect.com
Background and Objective: The nonapeptide hypothalamic hormone vasopressin (VP),
exerts important effects on cardiovascular system via its receptors V1, V2 and V3. Patients …