How do enzymes orient when trapped on metal–organic framework (MOF) surfaces?
Enzyme immobilization in metal–organic frameworks (MOFs) offers retained enzyme
integrity and activity, enhanced stability, and reduced leaching. Trapping enzymes on MOF …
integrity and activity, enhanced stability, and reduced leaching. Trapping enzymes on MOF …
Expanding the “library” of metal–organic frameworks for enzyme biomineralization
Metal–organic frameworks (MOFs) are advanced platforms for enzyme immobilization.
Enzymes can be entrapped via either diffusion (into pre-formed MOFs) or co-crystallization …
Enzymes can be entrapped via either diffusion (into pre-formed MOFs) or co-crystallization …
Size-tunable metal–organic framework-coated magnetic nanoparticles for enzyme encapsulation and large-substrate biocatalysis
Immobilizing enzymes on nanoparticles (NPs) enhances the cost-efficiency of biocatalysis;
however, when the substrates are large, it becomes difficult to separate the enzyme@ NP …
however, when the substrates are large, it becomes difficult to separate the enzyme@ NP …
Enzyme immobilization on graphite oxide (GO) surface via one-pot synthesis of GO/metal–organic framework composites for large-substrate biocatalysis
J Farmakes, I Schuster, A Overby… - … applied materials & …, 2020 - ACS Publications
Although enzyme immobilization has improved many areas, biocatalysis involving large-size
substrates is still challenging for immobilization platform design because of the protein …
substrates is still challenging for immobilization platform design because of the protein …
Metal–Organic Materials (MOMs) Enhance Proteolytic Selectivity, Efficiency, and Reusability of Trypsin: A Time-Resolved Study on Proteolysis
Proteases are involved in essential biological functions in nature and have become drug
targets recently. In spite of the promising progress, two challenges,(i) the intrinsic instability …
targets recently. In spite of the promising progress, two challenges,(i) the intrinsic instability …
One-pot synthesis of enzyme@ metal–organic material (MOM) biocomposites for enzyme biocatalysis
Metal–organic frameworks/materials (MOFs/MOMs) are advanced enzyme immobilization
platforms that improve biocatalysis, materials science, and protein biophysics. A unique way …
platforms that improve biocatalysis, materials science, and protein biophysics. A unique way …
Impact of Crystallinity on Enzyme Orientation and Dynamics upon Biomineralization in Metal–Organic Frameworks
Aqueous-phase co-crystallization (also known as biomimetic mineralization or
biomineralization) is a unique way to encapsulate large enzymes, enzyme clusters, and …
biomineralization) is a unique way to encapsulate large enzymes, enzyme clusters, and …
Unveiling the orientation and dynamics of enzymes in unstructured artificial compartments of metal–organic frameworks (MOFs)
Confining enzymes in well-shaped MOF compartments is a promising approach to mimic the
cellular environment of enzymes and determine enzyme structure–function relationship …
cellular environment of enzymes and determine enzyme structure–function relationship …