Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …

Abstract The sirtuins (SIRT1–7) are a family of nicotinamide adenine dinucleotide (NAD+)-
dependent deacylases with remarkable abilities to prevent diseases and even reverse …

The pursuit to discover the fundamental biology and mechanisms of aging within the context
of the physical and social environment is critical to designing interventions to prevent and …

The sirtuins (SIRTs; of which there are seven in mammals) are NAD+-dependent enzymes
that regulate a large number of cellular pathways and forestall the progression of ageing …

The presence of ROS is a constant feature in living cells metabolizing O2. ROS
concentration and compartmentation determine their physiological or pathological effects …

Mesenchymal stromal/stem cells (MSCs) are multipotent stem cells present in most fetal and
adult tissues. Ex vivo culture‐expanded MSCs are being investigated for tissue repair and …

Mammalian sirtuins have emerged in recent years as critical modulators of multiple
biological processes, regulating cellular metabolism, DNA repair, gene expression, and …

Abstract Sirtuins (SIRT1–SIRT7) are unique histone deacetylases (HDACs) whose activity
depends on NAD+ levels and thus on the cellular metabolic status. SIRTs regulate energy …

SIRT6, a member of the Sirtuin family of NAD+-dependent enzymes, has established roles in
chromatin signaling and genome maintenance. Through these functions, SIRT6 protects …

The biological functions of sirtuin 6 (SIRT6; eg, deacetylation, defatty‐acylation, and mono‐
ADP‐ribosylation) play a pivotal role in regulating lifespan and several fundamental …