Inspired by the success of fluorinated corticosteroids in the 1950s and fluoroquinolones in
the 1980s, fluorine-containing pharmaceuticals, which are also known as fluoro …

Currently, the chemistry of organofluorine compounds is a leading and rapidly developing
area of organic chemistry. Fluorine present in a molecule largely determines its specific …

The dual incorporation of two important functional groups—trifluoromethyl and cyano
moieties into one heterocyclic core in a single-step reaction represents an appealing but …

Direct access to pharmaceutically attractive benzo-fused nine-membered heterocyclic
alkenes 3 with a trifluoromethyl carbinol moiety was achieved via a palladium-catalyzed …

Fluorinated compounds attracted remarkable interest in recent decades. 1 Unique complex
of physicochemical and biological properties provided by incorporation of fluorine or …

Fluorinated quinolines and pyridines are prevalent pharmacophores, yet their synthesis is
often challenging. Herein, we demonstrate that dibromofluoromethane as …

Fluorine-containing heterocycles continue to receive considerable attention due to their
unique properties. In medicinal chemistry, the incorporation of fluorine in small molecules …

A copper-mediated synthesis of 4-(trifluoromethyl) pyrazoles is described. In one step from
readily accessible α, β-alkynic tosylhydrazones, a remarkable domino sequence of …

A detailed study of the reaction of trifluoroacetylated acetylenes and aryl (alkyl) hydrazines
was performed, aimed to the regioselective synthesis of 3-or 5-trifluoromethylated pyrazoles …

The tetrafluoro-λ6-sulfanyl (SF4) moiety has been relatively undeveloped since its discovery
in the 1970s. In this study, we synthesized pyridine–SF4–isoxazolines, in which the two …