Adherens junctions and desmosomes coordinate mechanics and signaling to orchestrate tissue morphogenesis and function: an evolutionary perspective
M Rübsam, JA Broussard… - Cold Spring …, 2018 - cshperspectives.cshlp.org
Cadherin-based adherens junctions (AJs) and desmosomes are crucial to couple
intercellular adhesion to the actin or intermediate filament cytoskeletons, respectively. As …
intercellular adhesion to the actin or intermediate filament cytoskeletons, respectively. As …
[HTML][HTML] Desmosomes: essential contributors to an integrated intercellular junction network
The development of adhesive connections between cells was critical for the evolution of
multicellularity and for organizing cells into complex organs with discrete compartments …
multicellularity and for organizing cells into complex organs with discrete compartments …
A glycine-specific N-degron pathway mediates the quality control of protein N-myristoylation
INTRODUCTION The ubiquitin-proteasome system is the major route through which the cell
achieves selective protein degradation. The E3 ubiquitin ligases are the major determinants …
achieves selective protein degradation. The E3 ubiquitin ligases are the major determinants …
Evolution and diversity of cadherins and catenins
Cadherin genes encode a superfamily of conserved transmembrane proteins that share an
adhesive ectodomain composed of tandem cadherin repeats. More than 100 human …
adhesive ectodomain composed of tandem cadherin repeats. More than 100 human …
CRISPR/Cas9 library screening uncovered methylated PKP2 as a critical driver of lung cancer radioresistance by stabilizing β-catenin
C Cheng, X Pei, SW Li, J Yang, C Li, J Tang, K Hu… - Oncogene, 2021 - nature.com
Radiation resistance is a major cause of lung cancer treatment failure. Armadillo (ARM)
superfamily proteins participate in various fundamental cellular processes; however …
superfamily proteins participate in various fundamental cellular processes; however …
[HTML][HTML] Tracing the evolutionary origin of desmosomes
KJ Green, Q Roth-Carter, CM Niessen, SA Nichols - Current Biology, 2020 - cell.com
Cadherin-based cell–cell junctions help metazoans form polarized sheets of cells, which are
necessary for the development of organs and the compartmentalization of functions. The …
necessary for the development of organs and the compartmentalization of functions. The …
The formin INF2 in disease: progress from 10 years of research
L Labat-de-Hoz, MA Alonso - Cellular and Molecular Life Sciences, 2020 - Springer
Formins are a conserved family of proteins that primarily act to form linear polymers of actin.
Despite their importance to the normal functioning of the cytoskeleton, for a long time, the …
Despite their importance to the normal functioning of the cytoskeleton, for a long time, the …
[HTML][HTML] SmgGDS: an emerging master regulator of prenylation and trafficking by small GTPases in the Ras and Rho families
AC Brandt, OJ Koehn, CL Williams - Frontiers in Molecular …, 2021 - frontiersin.org
Newly synthesized small GTPases in the Ras and Rho families are prenylated by cytosolic
prenyltransferases and then escorted by chaperones to membranes, the nucleus, and other …
prenyltransferases and then escorted by chaperones to membranes, the nucleus, and other …
Structure of the nucleation‐promoting factor SPIN 90 bound to the actin filament nucleator Arp2/3 complex
Unlike the WASP family of Arp2/3 complex activators, WISH/DIP/SPIN 90 (WDS) family
proteins activate actin filament nucleation by the Arp2/3 complex without the need for a …
proteins activate actin filament nucleation by the Arp2/3 complex without the need for a …
[HTML][HTML] Genome-wide discovery, and computational and transcriptional characterization of an AIG gene family in the freshwater snail Biomphalaria glabrata, a vector …
Abstract Background The AIG (avrRpt2-induced gene) family of GTPases, characterized by
the presence of a distinctive AIG1 domain, is mysterious in having a peculiar phylogenetic …
the presence of a distinctive AIG1 domain, is mysterious in having a peculiar phylogenetic …