The number of patients with acquired immunodeficiency has grown steadily as a result of
both a larger number of patients receiving solid organ and hematopoietic stem cell …

Medical advances such as allogeneic transplantation can expose patients to periods of
marked immunosuppression, during which viral infections are an important cause of …

Immunocompromised individuals are at high risk for life-threatening diseases, especially
those caused by cytomegalovirus (CMV), Epstein-Barr virus (EBV) and adenovirus …

Adenoviruses are increasingly recognized as contributors to morbidity and mortality among
stem cell and solid-organ transplant recipients. Clinical presentations range from …

Viral infection or reactivation remains a major cause of morbidity and mortality after
allogeneic stem cell transplantation. We now show that infusions of single cytotoxic T …

Epstein Barr virus (EBV)+ Hodgkin's disease (HD) expresses clearly identified tumor
antigens derived from the virus and could, in principle, be a target for adoptive …

Severe and fatal viral infections remain common after hematopoietic stem cell
transplantation. Adoptive transfer of cytotoxic T lymphocytes (CTLs) specific for Epstein–Barr …

Adoptive transfer of Epstein Barr virus (EBV)–specific cytotoxic T-lymphocytes (EBV-CTLs)
has shown that these cells persist in patients with EBV+ Hodgkin lymphoma (HD) to produce …

The clinical manufacture of antigen-specific cytotoxic T lymphocytes (CTLs) for adoptive
immunotherapy is limited by the complexity and time required to produce large numbers with …

Recombinant viruses hold promise as vectors for vaccines to prevent infectious diseases
with significant global health impacts. One of their major limitations is that preexisting anti …