The hematopoietic cell kinase (HCK) is a member of the SRC family of cytoplasmic tyrosine
kinases (SFKs), and is expressed in cells of the myeloid and B-lymphocyte cell lineages …

While significant progress has been made in terms of human immunodeficiency virus (HIV)
therapy, treatment does not represent a cure and remains inaccessible to many people …

The immune system of vertebrate species consists of many different cell types that have
distinct functional roles and are subject to different evolutionary pressures. Here, we first …

Overexpression of the myeloid Src-family kinases Fgr and Hck has been linked to the
development of acute myeloid leukemia (AML). Here we characterized the contribution of …

Stem cells hold great promise as a means of treating otherwise incurable, degenerative
diseases due to their ability both to self-renew and differentiate. However, stem cell damage …

Mononuclear phagocytes (MP) comprise monocytes, macrophages (MΦ) and dendritic cells
(DC), including their lineage‐committed progenitors, which together have an eminent role in …

Tissue infiltration of phagocytes exacerbates several human pathologies including chronic
inflammations or cancers. However, the mechanisms involved in macrophage migration …

Tumor-associated macrophages are known to amplify the malignant potential of tumors by
secreting a variety of cytokines and proteases involved in tumor cell invasion and …

Macrophage tissue infiltration is a hallmark of several pathological situations including
cancer, neurodegenerative disorders and chronic inflammation. Hence, deciphering the …

Hematopoietic cell kinase (Hck) is a member of the Src family and is expressed in
hematopoietic cells. By regulating multiple signaling pathways, HCK can interact with …