Purinergic signalling in the musculoskeletal system
It is now widely recognised that extracellular nucleotides, signalling via purinergic receptors,
participate in numerous biological processes in most tissues. It has become evident that …
participate in numerous biological processes in most tissues. It has become evident that …
Ion channels in osteoarthritis: emerging roles and potential targets
Osteoarthritis (OA) is a highly prevalent joint disease that causes substantial disability, yet
effective approaches to disease prevention or to the delay of OA progression are lacking …
effective approaches to disease prevention or to the delay of OA progression are lacking …
In pursuit of P2X3 antagonists: novel therapeutics for chronic pain and afferent sensitization
AP Ford - Purinergic signalling, 2012 - Springer
Treating pain by inhibiting ATP activation of P2X3-containing receptors heralds an exciting
new approach to pain management, and Afferent's program marks the vanguard in a new …
new approach to pain management, and Afferent's program marks the vanguard in a new …
Purinergic signalling and bone remodelling
Accumulating evidence suggests that extracellular nucleotides, signalling through P2
receptors, could play an important role in modulating bone cell function. ATP and other …
receptors, could play an important role in modulating bone cell function. ATP and other …
Articular chondrocytes express connexin 43 hemichannels and P2 receptors–a putative mechanoreceptor complex involving the primary cilium?
Mechanical loading is essential for the health and homeostasis of articular cartilage,
although the fundamental mechanotransduction pathways are unclear. Previous studies …
although the fundamental mechanotransduction pathways are unclear. Previous studies …
[PDF][PDF] Calcium signalling in chondrogenesis: implications for cartilage repair
Introduction 3. Adult mesenchymal stem cells in cartilage repair 4. Articular cartilage: from
structure to function 5. Chondrogenesis is regulated by interplay between numerous intra …
structure to function 5. Chondrogenesis is regulated by interplay between numerous intra …
Purinergic system signaling in metainflammation-associated osteoarthritis
P Gratal, A Lamuedra, JP Medina… - Frontiers in …, 2020 - frontiersin.org
Inflammation triggered by metabolic imbalance, also called metainflammation, is low-grade
inflammation caused by the components involved in metabolic syndrome (MetS), including …
inflammation caused by the components involved in metabolic syndrome (MetS), including …
Blocking of the P2X7 receptor inhibits the activation of the MMP-13 and NF-κB pathways in the cartilage tissue of rats with osteoarthritis
H Hu, B Yang, Y Li, S Zhang… - … journal of molecular …, 2016 - spandidos-publications.com
Abstract P2X purinoceptor 7 (P2X7) receptor (P2X7R) is known to play a significant role in
inflammation and pain-causing diseases, including osteoarthritis (OA). However, the …
inflammation and pain-causing diseases, including osteoarthritis (OA). However, the …
Store-operated calcium entry and calcium influx via voltage-operated calcium channels regulate intracellular calcium oscillations in chondrogenic cells
Chondrogenesis is known to be regulated by calcium-dependent signalling pathways in
which temporal aspects of calcium homeostasis are of key importance. We aimed to better …
which temporal aspects of calcium homeostasis are of key importance. We aimed to better …
P2X3 and P2X2/3 receptors play a crucial role in articular hyperalgesia development through inflammatory mechanisms in the knee joint experimental synovitis
Osteoarthritis (OA) is a degenerative and progressive disease characterized by cartilage
breakdown and by synovial membrane inflammation, which results in disability, joint …
breakdown and by synovial membrane inflammation, which results in disability, joint …