Control of metastasis by NK cells
The metastatic spread of malignant cells to distant anatomical locations is a prominent
cause of cancer-related death. Metastasis is governed by cancer-cell-intrinsic mechanisms …
cause of cancer-related death. Metastasis is governed by cancer-cell-intrinsic mechanisms …
EMT transcription factors in cancer development re-evaluated: Beyond EMT and MET
S Goossens, N Vandamme, P Van Vlierberghe… - … et Biophysica Acta (BBA …, 2017 - Elsevier
Reactivation of an embryonic epithelial-to-mesenchymal (EMT) program is commonly
accepted as a core component of carcinoma progression. Collectively, EMT and …
accepted as a core component of carcinoma progression. Collectively, EMT and …
Hematopoietic cell transplantation donor-derived memory-like NK cells functionally persist after transfer into patients with leukemia
MM Berrien-Elliott, JA Foltz… - Science translational …, 2022 - science.org
Natural killer (NK) cells are innate lymphoid cells that eliminate cancer cells, produce
cytokines, and are being investigated as a nascent cellular immunotherapy. Impaired NK …
cytokines, and are being investigated as a nascent cellular immunotherapy. Impaired NK …
Heterogeneity of human bone marrow and blood natural killer cells defined by single-cell transcriptome
C Yang, JR Siebert, R Burns, ZJ Gerbec… - Nature …, 2019 - nature.com
Natural killer (NK) cells are critical to both innate and adaptive immunity. However, the
development and heterogeneity of human NK cells are yet to be fully defined. Using single …
development and heterogeneity of human NK cells are yet to be fully defined. Using single …
[HTML][HTML] Sphingosine 1-phosphate receptor 5 (S1PR5) regulates the peripheral retention of tissue-resident lymphocytes
Tissue-resident memory T (TRM) cells provide long-lasting immune protection. One of the
key events controlling TRM cell development is the local retention of TRM cell precursors …
key events controlling TRM cell development is the local retention of TRM cell precursors …
A2AR adenosine signaling suppresses natural killer cell maturation in the tumor microenvironment
Extracellular adenosine is a key immunosuppressive metabolite that restricts activation of
cytotoxic lymphocytes and impairs antitumor immune responses. Here, we show that …
cytotoxic lymphocytes and impairs antitumor immune responses. Here, we show that …
SMAD4 impedes the conversion of NK cells into ILC1-like cells by curtailing non-canonical TGF-β signaling
Among the features that distinguish type 1 innate lymphoid cells (ILC1s) from natural killer
(NK) cells is a gene signature indicative of'imprinting'by cytokines of the TGF-β family. We …
(NK) cells is a gene signature indicative of'imprinting'by cytokines of the TGF-β family. We …
Multi-tissue single-cell analysis deconstructs the complex programs of mouse natural killer and type 1 innate lymphoid cells in tissues and circulation
Natural killer (NK) cells and type 1 innate lymphoid cells (ILC1s) are heterogenous innate
lymphocytes broadly defined in mice as Lin− NK1. 1+ NKp46+ cells that express the …
lymphocytes broadly defined in mice as Lin− NK1. 1+ NKp46+ cells that express the …
Efficiency and target derepression of anti-miR-92a: results of a first in human study
MicroRNA (miRNA) inhibition is a promising therapeutic strategy in several disease
indications. MRG-110 is a locked nucleic acid-based antisense oligonucleotide that targets …
indications. MRG-110 is a locked nucleic acid-based antisense oligonucleotide that targets …
Control of nutrient uptake by IRF4 orchestrates innate immune memory
Natural killer (NK) cells are innate cytotoxic lymphocytes with adaptive immune features,
including antigen specificity, clonal expansion and memory. As such, NK cells share many …
including antigen specificity, clonal expansion and memory. As such, NK cells share many …