Pharmaceutical and medicinal significance of sulfur (SVI)-Containing motifs for drug discovery: A critical review
Sulfur (S VI) based moieties, especially, the sulfonyl or sulfonamide based analogues have
showed a variety of pharmacological properties, and its derivatives propose a high degree …
showed a variety of pharmacological properties, and its derivatives propose a high degree …
1, 3, 4-thiadiazole: A privileged scaffold for drug design and development
X Han, YL Yu, YS Hu, XH Liu - Current Topics in Medicinal …, 2021 - ingentaconnect.com
1, 3, 4-thiadiazole is a five-membered aromatic heterocycle containing two nitrogen atoms
and one sulfur atom. As a privileged scaffold, it has its unique chemical properties and …
and one sulfur atom. As a privileged scaffold, it has its unique chemical properties and …
Synthesis, X-ray structure, vibrational spectroscopy, DFT, biological evaluation and molecular docking studies of (E)-N'-(4-(dimethylamino) benzylidene)-5-methyl-1H …
K Karrouchi, SA Brandán, Y Sert, H El-Marzouqi… - Journal of Molecular …, 2020 - Elsevier
Abstract New crystal,(E)-N'-(4-(dimethylamino) benzylidene)-5-methyl-1H-pyrazole-3-
carbohydrazide (3) has been synthesized and characterized by FT-IR, NMR, ESI-MS and …
carbohydrazide (3) has been synthesized and characterized by FT-IR, NMR, ESI-MS and …
Synthesis, biological evaluation and in silico studies of novel N-substituted phthalazine sulfonamide compounds as potent carbonic anhydrase and …
The synthesis, characterization and biological evaluation of a series of novel N-substituted
phthalazine sulfonamide (5a-l) are disclosed. Phthalazines which are nitrogen-containing …
phthalazine sulfonamide (5a-l) are disclosed. Phthalazines which are nitrogen-containing …
The behavior of some chalcones on acetylcholinesterase and carbonic anhydrase activity
Carbonic anhydrase (CA) has a key role in respiration, carbon dioxide and bicarbonate
transport. Acetylcholinesterase (AChE) is a serine hydrolase and mostly abundant at …
transport. Acetylcholinesterase (AChE) is a serine hydrolase and mostly abundant at …
Recent advances in biological active sulfonamide based hybrid compounds Part A: Two-component sulfonamide hybrids
Sulfonamides constitute an important class of drugs, with many types of pharmacological
agents possessing antibacterial, anti-carbonic anhydrase, anti-obesity, diuretic …
agents possessing antibacterial, anti-carbonic anhydrase, anti-obesity, diuretic …
Design and synthesis of novel pyrazole-substituted different nitrogenous heterocyclic ring systems as potential anti-inflammatory agents
ES Nossier, HH Fahmy, NM Khalifa, WI El-Eraky… - Molecules, 2017 - mdpi.com
With the aim of developing novel anti-inflammatory scaffolds, a new series of pyrazole-
substituted various nitrogenous heterocyclic ring systems at C-4 position were synthesized …
substituted various nitrogenous heterocyclic ring systems at C-4 position were synthesized …
Recent advances in biological active sulfonamide based hybrid compounds part C: Multicomponent sulfonamide hybrids
Sulfonamides, with the general formula R-SO2NR1R2, have attracted great attention since
the early discovery of sulfonamide-containing antibacterial drugs. The combinations of …
the early discovery of sulfonamide-containing antibacterial drugs. The combinations of …
Potential inhibitors of human carbonic anhydrase isozymes I and II: Design, synthesis and docking studies of new 1, 3, 4-thiadiazole derivatives
In the last years, inhibition of carbonic anhydrase (CA) has emerged as a promising
approach for pharmacologic intervention in a variety of disorders such as glaucoma …
approach for pharmacologic intervention in a variety of disorders such as glaucoma …
The in vitro impacts of some plant extracts on carbonic anhydrase i, ii and paraoxonase-1
The presented article focuses on the in vitro inhibition of plant extracts on the human
carbonic anhydrase isoforms (hCA I and hCAII), and paraoxonase-1 (PON1) activities. Five …
carbonic anhydrase isoforms (hCA I and hCAII), and paraoxonase-1 (PON1) activities. Five …