Spinal cord injury: molecular mechanisms and therapeutic interventions

X Hu, W Xu, Y Ren, Z Wang, X He, R Huang… - Signal transduction and …, 2023 - nature.com
Spinal cord injury (SCI) remains a severe condition with an extremely high disability rate.
The challenges of SCI repair include its complex pathological mechanisms and the …

Natural and targeted circuit reorganization after spinal cord injury

MA Anderson, JW Squair, M Gautier, TH Hutson… - Nature …, 2022 - nature.com
A spinal cord injury disrupts communication between the brain and the circuits in the spinal
cord that regulate neurological functions. The consequences are permanent paralysis, loss …

A universal interface for plug-and-play assembly of stretchable devices

Y Jiang, S Ji, J Sun, J Huang, Y Li, G Zou, T Salim… - Nature, 2023 - nature.com
Stretchable hybrid devices have enabled high-fidelity implantable,–and on-skin,–monitoring
of physiological signals. These devices typically contain soft modules that match the …

Activity-dependent spinal cord neuromodulation rapidly restores trunk and leg motor functions after complete paralysis

A Rowald, S Komi, R Demesmaeker, E Baaklini… - Nature medicine, 2022 - nature.com
Epidural electrical stimulation (EES) targeting the dorsal roots of lumbosacral segments
restores walking in people with spinal cord injury (SCI). However, EES is delivered with …

A chemically mediated artificial neuron

T Wang, M Wang, J Wang, L Yang, X Ren, G Song… - Nature …, 2022 - nature.com
Brain–machine interfaces typically rely on electrophysiological signals to interpret and
transmit neurological information. In biological systems, however, neurotransmitters are …

Injectable tissue prosthesis for instantaneous closed-loop rehabilitation

S Jin, H Choi, D Seong, CL You, JS Kang, S Rho… - Nature, 2023 - nature.com
To construct tissue-like prosthetic materials, soft electroactive hydrogels are the best
candidate owing to their physiological mechanical modulus, low electrical resistance and …

[HTML][HTML] The neurons that restore walking after paralysis

C Kathe, MA Skinnider, TH Hutson, N Regazzi… - Nature, 2022 - nature.com
A spinal cord injury interrupts pathways from the brain and brainstem that project to the
lumbar spinal cord, leading to paralysis. Here we show that spatiotemporal epidural …

Pathophysiology and therapeutic approaches for spinal cord injury

R Lima, A Monteiro, AJ Salgado, S Monteiro… - International Journal of …, 2022 - mdpi.com
Spinal cord injury (SCI) is a disabling condition that disrupts motor, sensory, and autonomic
functions. Despite extensive research in the last decades, SCI continues to be a global …

Epidural spinal cord stimulation as an intervention for motor recovery after motor complete spinal cord injury

JT Hachmann, A Yousak, JJ Wallner… - Journal of …, 2021 - journals.physiology.org
Spinal cord injury (SCI) commonly results in permanent loss of motor, sensory, and
autonomic function. Recent clinical studies have shown that epidural spinal cord stimulation …

Non-invasive spinal cord electrical stimulation for arm and hand function in chronic tetraplegia: a safety and efficacy trial

C Moritz, EC Field-Fote, C Tefertiller, I van Nes… - Nature medicine, 2024 - nature.com
Cervical spinal cord injury (SCI) leads to permanent impairment of arm and hand functions.
Here we conducted a prospective, single-arm, multicenter, open-label, non-significant risk …