The division of medulloblastoma into different subgroups by microarray expression profiling
has dramatically changed our perspective of this malignant childhood brain tumour. Now …

Endoplasmic reticulum (ER)‐localized enzymes synthesize the vast majority of cellular
lipids. The ER therefore has a major influence on cellular lipid biomass and balances the …

Medulloblastoma is an aggressively growing tumour, arising in the cerebellum or
medulla/brain stem. It is the most common malignant brain tumour in children, and shows …

Lipid composition determines organelle identity; however, whether the lipid composition of
the inner nuclear membrane (INM) domain of the ER contributes to its identity is not known …

Lipins are phosphatidate phosphatases that generate diacylglycerol (DAG). In this study, we
report that yeast lipin, Pah1p, controls the formation of cytosolic lipid droplets. Disruption of …

The size of the nucleus scales robustly with cell size so that the nuclear-to-cell volume ratio
(N/C ratio) is maintained during cell growth in many cell types. The mechanism responsible …

Phosphatases of the haloacid dehalogenase (HAD) superfamily of hydrolases are an
ancient and very large class of enzymes that have evolved to dephosphorylate a wide range …

Failure to reorganize the endoplasmic reticulum (ER) in mitosis results in chromosome
missegregation. Here, we show that accurate chromosome segregation in human cells …

Phospholipid biosynthesis is essential for the construction of most eukaryotic cell
membranes, but how this process is regulated in plants remains poorly understood. Here …

In addition to the major serine/threonine-specific phosphoprotein phosphatase, Mg 2+-
dependent phosphoprotein phosphatase, and protein tyrosine phosphatase families, there …