Activity-based sensing (ABS) offers a general approach that exploits chemical reactivity as a
method for selective detection and manipulation of biological analytes. Here, we illustrate …

Protein synthesis is essential to support homeostasis, and thus, must be highly regulated
during cellular response to harmful environments. All stages of translation are susceptible to …

Histone modifications coupled to transcription elongation play important roles in regulating
the accuracy and efficiency of gene expression. The monoubiquitylation of a conserved …

This study investigated the efficacy of trans-2-hexenal in preventing green mold on
postharvest citrus fruit and its mode of action against imazalil-resistant Penicillium digitatum …

In response to oxidative stress cells reprogram gene expression to enhance levels of
antioxidant enzymes and promote survival. In Saccharomyces cerevisiae the polysome …

It is known that mRNAs and the machinery that translates them are not uniformly distributed
throughout the cytoplasm. As a result, the expression of some genes is localized to particular …

Oxidative stress causes K63-linked ubiquitination of ribosomes by the E2 ubiquitin
conjugase Rad6. How Rad6-mediated ubiquitination of ribosomes affects translation …

The E2 ubiquitin conjugator Rad6 is required for DNA damage bypass in budding yeast but
remain functionally unknown in filamentous fungi. Here, we report pleiotropic effect of Rad6 …

Oxidative post-translational modifications of protein thiols are well recognized as a readily
occurring alteration of proteins, which can modify their function and thus control cellular …

Protein ubiquitination is essential to govern cells' ability to cope with harmful environments
by regulating many aspects of protein dynamics from synthesis to degradation. As important …