Hepatic cholesterol transport and its role in non-alcoholic fatty liver disease and atherosclerosis

H Li, XH Yu, X Ou, XP Ouyang, CK Tang - Progress in lipid research, 2021 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is a quickly emerging global health problem
representing the most common chronic liver disease in the world. Atherosclerotic …

The interdependency and co-regulation of the vitamin D and cholesterol metabolism

T Warren, R McAllister, A Morgan, TS Rai, V McGilligan… - Cells, 2021 - mdpi.com
Vitamin D and cholesterol metabolism overlap significantly in the pathways that contribute to
their biosynthesis. However, our understanding of their independent and co-regulation is …

The Chicken Pan-Genome Reveals Gene Content Variation and a Promoter Region Deletion in IGF2BP1 Affecting Body Size

K Wang, H Hu, Y Tian, J Li, A Scheben… - Molecular biology …, 2021 - academic.oup.com
Domestication and breeding have reshaped the genomic architecture of chicken, but the
retention and loss of genomic elements during these evolutionary processes remain …

The role of RNA m6A methylation in lipid metabolism

Y Wang, Y Wang, J Gu, T Su, X Gu… - Frontiers in …, 2022 - frontiersin.org
The m6A methylation is the most numerous modification of mRNA in mammals, coordinated
by RNA m6A methyltransferases, RNA m6A demethylases, and RNA m6A binding proteins …

Role of podocyte injury in glomerulosclerosis

CC Lu, GH Wang, J Lu, PP Chen, Y Zhang… - Renal fibrosis …, 2019 - Springer
Finding new therapeutic targets of glomerulosclerosis treatment is an ongoing quest. Due to
a living environment of various stresses and pathological stimuli, podocytes are prone to …

Oxidative Stress and Lipid Accumulation Augments Cell Death in LDLR-Deficient RPE Cells and Ldlr −/− Mice

PG Sreekumar, F Su, C Spee, E Araujo, S Nusinowitz… - Cells, 2022 - mdpi.com
Lipid peroxidation from oxidative stress is considered a major contributor to age-related
macular degeneration (AMD). The retina is abundant with circulating low-density …

Aging fits the disease criteria of the international classification of diseases

D Khaltourina, Y Matveyev, A Alekseev… - Mechanisms of ageing …, 2020 - Elsevier
The disease criteria used by the World Health Organization (WHO) were applied to human
biological aging in order to assess whether aging can be classified as a disease. These …

PCSK9 signaling pathways and their potential importance in clinical practice

M Wiciński, J Żak, B Malinowski, G Popek, G Grześk - EPMA Journal, 2017 - Springer
In the following review, authors described the structure and biochemical pathways of
PCSK9, its involvement in LDL metabolism, as well as significances of proprotein …

[HTML][HTML] Proprotein convertase subtilisin/kexin type 9 targets megalin in the kidney proximal tubule and aggravates proteinuria in nephrotic syndrome

CK Skeby, S Hummelgaard, C Gustafsen, F Petrillo… - Kidney International, 2023 - Elsevier
Proteinuria is a prominent feature of chronic kidney disease. Interventions that reduce
proteinuria slow the progression of chronic kidney disease and the associated risk of …

Phytosterol of lotus seed core powder alleviates hypercholesterolemia by regulating gut microbiota in high-cholesterol diet-induced C57BL/6J mice

D Liu, J Pi, B Zhang, H Zeng, C Li, Z Xiao, F Fang… - Food Bioscience, 2023 - Elsevier
The present study aimed to investigate the regulatory mechanisms of lotus seed core
powder phytosterol extract (LSP-PE) on hypercholesterolemia and intestinal microbiota in …