Mitochondria are organelles with vital functions in almost all eukaryotic cells. Often
described as the cellular 'powerhouses' due to their essential role in aerobic oxidative …

Metabolic networks are fundamental to cellular processes, driving energy production,
biosynthesis, redox regulation, and cellular signaling. Recent advancements in metabolic …

The ability to balance conflicting functional demands is critical for ensuring organismal
survival. The transcription and repair of the mitochondrial genome (mtDNA) requires …

Mitochondria are the main source of energy used to maintain cellular homeostasis. This
aspect of mitochondrial biology underlies their putative role in age-associated tissue …

Caenorhabditis elegans (C. elegans) is a nematode present worldwide. The worm shows
homology to mammalian systems and expresses approximately 40% of human disease …

Electron transport chain (ETC) dysfunction is a common feature of mitochondrial diseases
and induces severe cellular stresses, including mitochondrial membrane potential (Δψm) …

Mitochondria generate the energy to sustain cell viability and serve as a hub for cell
signalling. Their own genome (mtDNA) encodes genes critical for oxidative phosphorylation …

Caenorhabditis elegans is a valuable model organism in biomedical research that has led to
major discoveries in the fields of neurodegeneration, cancer and aging. Because movement …

Understanding radiation‐induced non‐cancer effects on the central nervous system (CNS)
is essential for the risk assessment of medical (eg, radiotherapy) and occupational (eg …

Aberration of mitochondrial function is a shared feature of many human pathologies,
characterised by changes in metabolic flux, cellular energetics, morphology, composition …