ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response
AN Blackford, SP Jackson - Molecular cell, 2017 - cell.com
In vertebrate cells, the DNA damage response is controlled by three related kinases: ATM,
ATR, and DNA-PK. It has been 20 years since the cloning of ATR, the last of the three to be …
ATR, and DNA-PK. It has been 20 years since the cloning of ATR, the last of the three to be …
Effects of hyperthermia on DNA repair pathways: one treatment to inhibit them all
The currently available arsenal of anticancer modalities includes many DNA damaging
agents that can kill malignant cells. However, efficient DNA repair mechanisms protect both …
agents that can kill malignant cells. However, efficient DNA repair mechanisms protect both …
Significance analysis of microarrays applied to the ionizing radiation response
VG Tusher, R Tibshirani, G Chu - Proceedings of the …, 2001 - National Acad Sciences
Microarrays can measure the expression of thousands of genes to identify changes in
expression between different biological states. Methods are needed to determine the …
expression between different biological states. Methods are needed to determine the …
[HTML][HTML] Homologous recombination and non‐homologous end‐joining pathways of DNA double‐strand break repair have overlapping roles in the maintenance of …
M Takata, MS Sasaki, E Sonoda, C Morrison… - The EMBO …, 1998 - embopress.org
Eukaryotic cells repair DNA double‐strand breaks (DSBs) by at least two pathways,
homologous recombination (HR) and non‐homologous end‐joining (NHEJ). Rad54 …
homologous recombination (HR) and non‐homologous end‐joining (NHEJ). Rad54 …
The Ku heterodimer: function in DNA repair and beyond
VL Fell, C Schild-Poulter - Mutation Research/Reviews in Mutation …, 2015 - Elsevier
Ku is an abundant, highly conserved DNA binding protein found in both prokaryotes and
eukaryotes that plays essential roles in the maintenance of genome integrity. In eukaryotes …
eukaryotes that plays essential roles in the maintenance of genome integrity. In eukaryotes …
Recognition, signaling, and repair of DNA double-strand breaks produced by ionizing radiation in mammalian cells: the molecular choreography
LH Thompson - Mutation Research/Reviews in Mutation Research, 2012 - Elsevier
The faithful maintenance of chromosome continuity in human cells during DNA replication
and repair is critical for preventing the conversion of normal diploid cells to an oncogenic …
and repair is critical for preventing the conversion of normal diploid cells to an oncogenic …
The DNA-dependent protein kinase
GCM Smith, SP Jackson - Genes & development, 1999 - genesdev.cshlp.org
The DNA-dependent protein kinase (DNA–PK) is a nuclear serine/threonine protein kinase
that is activated upon association with DNA. Biochemical and genetic data have revealed …
that is activated upon association with DNA. Biochemical and genetic data have revealed …
Saccharomyces cerevisiae Ku70 potentiates illegitimate DNA double‐strand break repair and serves as a barrier to error‐prone DNA repair pathways.
SJ Boulton, SP Jackson - The EMBO journal, 1996 - embopress.org
Ku, a heterodimer of polypeptides of approximately 70 kDa and 80 kDa (Ku70 and Ku80,
respectively), binds avidly to DNA double‐strand breaks (DSBs). Mammalian cells defective …
respectively), binds avidly to DNA double‐strand breaks (DSBs). Mammalian cells defective …
Defective DNA-dependent protein kinase activity is linked to V (D) J recombination and DNA repair defects associated with the murine scid mutation
T Blunt, NJ Finnie, GE Taccioli, GCM Smith… - Cell, 1995 - cell.com
Murine cells homozygous for the severe combined immune deficiency mutation (scid) and
V3 mutant hamster cells fall into the same complementation group and show similar defects …
V3 mutant hamster cells fall into the same complementation group and show similar defects …
[HTML][HTML] The multifaceted roles of Ku70/80
S Zahid, M Seif El Dahan, F Iehl… - International Journal of …, 2021 - mdpi.com
DNA double-strand breaks (DSBs) are accidental lesions generated by various endogenous
or exogenous stresses. DSBs are also genetically programmed events during the V (D) J …
or exogenous stresses. DSBs are also genetically programmed events during the V (D) J …