Zinc is a ubiquitous biological metal in all living organisms. The spatiotemporal zinc
dynamics in cells provide crucial cellular signaling opportunities, but also challenges for …

Nearly sixty years ago Fredrich Timm developed a histochemical technique that revealed a
rich reserve of free zinc in distinct regions of the brain. Subsequent electron microscopy …

Zinc is essential for all organisms and yet detrimental at elevated levels. Hence,
homeostasis of this metal is tightly regulated. The Zrt/Irt-like proteins (ZIPs) represent the …

The Zrt‐/Irt‐like protein (ZIP) family consists of divalent metal transporters, ubiquitous in all
kingdoms of life. Since the discovery of the first ZIPs in the 1990s, the ZIP family has been …

The second abundant micronutrient, zinc, is attracting more and more attention for it
performs essential functions in living organisms and bears close relationships with the …

Metal clusters are exploited by numerous metalloenzymes for catalysis, but it is not common
to utilize a metal cluster for substrate transport across membrane. The recent crystal …

Zinc is an essential nutrient for all organisms because this metal serves as a critical
structural or catalytic cofactor for many proteins. These zinc-dependent proteins are …

Abstract The Zrt/Irt-like protein (ZIP) metal transporters are key players in maintaining the
homeostasis of a panel of essential microelements. The prototypical ZIP from Bordetella …

The ZIP (Zrt and Irt-like proteins) protein family includes transporters responsible for the
translocation of zinc and other transition metals, such as iron and cadmium, between the …

Zinc signaling adds a similarly complex regulatory system to calcium signaling and extends
signaling with metal ions to lower concentrations. Zinc ions have intracellular and …