Viruses of archaea represent one of the most enigmatic parts of the virosphere. Most of the
characterized archaeal viruses infect extremophilic hosts and display remarkable diversity of …

Extreme thermoacidophiles (T opt> 65° C, pHopt< 3.5) inhabit unique environments fraught
with challenges, including extremely high temperatures, low pH, as well as high levels of …

Viruses employ a range of strategies to counteract the prokaryotic adaptive immune system,
clustered regularly interspaced short palindromic repeats and CRISPR-associated proteins …

Bacteria and archaea possess a striking diversity of CRISPR-Cas systems divided into six
types, posing a significant barrier to viral infection. As part of the virus-host arms race …

Extremophiles, microorganisms thriving in extreme environmental conditions, must have
proteins and nucleic acids that are stable at extremes of temperature and pH. The …

Multiple sclerosis (MS) is a complex multifactorial disease of the central nervous system
(CNS) for which animal models have mainly addressed downstream immunopathology but …

Despite a wide presence of type III clustered regularly interspaced short palindromic
repeats, CRISPR-associated (CRISPR-Cas) in archaea and bacteria, very few anti-CRISPR …

Archaeal viruses display unusually high genetic and morphological diversity. Studies of
these viruses proved to be instrumental for the expansion of knowledge on viral diversity …

Prokaryotic CRISPR–Cas immune systems are classified into six types based on their
effector complexes which cleave dsDNA specifically (types I, II and V), ssRNA exclusively …

CRISPR-Cas (clustered regularly interspaced short palindromic repeats and the associated
genes) constitute adaptive immune systems in bacteria and archaea and they provide …