Rationale There is no consensus on criteria to include in an asthma remission definition in
real life. Factors associated with achieving remission after biologic initiation remain poorly …

Background Investigation for the presence of asthma comorbidities is recommended by the
Global Initiative for Asthma because their presence can complicate asthma management …

Many different phenotypes that characterize severe asthma are supported by intricate
pathomechanisms called endotypes. The latter are driven by molecular interactions …

Background There is little agreement on clinically useful criteria for identifying real-world
responders to biologic treatments for asthma. Objective To investigate the impact of pre …

Background Exacerbation frequency strongly influences treatment choices in patients with
severe asthma. Research Question What is the extent of the variability of exacerbations rate …

Background To date, studies investigating the association between pre-biologic biomarker
levels and post-biologic outcomes have been limited to single biomarkers and assessment …

Background Biologic effectiveness is often assessed as response, a term that eludes
consistent definition. Identifying those most likely to respond in real-life has proven …

From 2014, the Global Initiative for Asthma (GINA) has focused on asthma control and
personalized management of patients' modifiable risk factors, including comorbidities1, 2 …