The angiotensin AT2 receptor: from a binding site to a novel therapeutic target

UM Steckelings, RE Widdop, ED Sturrock… - Pharmacological …, 2022 - Elsevier
Discovered more than 30 years ago, the angiotensin AT 2 receptor (AT 2 R) has evolved
from a binding site with unknown function to a firmly established major effector within the …

The renin-angiotensin-aldosterone system (RAAS) signaling pathways and cancer: foes versus allies

B Hassani, Z Attar, N Firouzabadi - Cancer Cell International, 2023 - Springer
The renin-angiotensin-aldosterone system (RAAS), is an old system with new fundamental
roles in cancer biology which influences cell growth, migration, death, and metastasis. RAAS …

LncRNA LINC00662 promotes colon cancer tumor growth and metastasis by competitively binding with miR-340-5p to regulate CLDN8/IL22 co-expression and …

B Cheng, A Rong, Q Zhou, W Li - Journal of Experimental & Clinical …, 2020 - Springer
Background LncRNA LINC00662 is closely related to the occurrence and development of
cancer. This study aims to explore the effect of LINC00662 on colon cancer tumor growth …

The role of the renin‐angiotensin system in skin physiology and pathophysiology

IMS Silva, KB Assersen, NN Willadsen… - Experimental …, 2020 - Wiley Online Library
Since its first description around the year 2000, the local renin‐angiotensin system (RAS) in
skin has been subject of an increasing number of studies with many additions over the last …

Angiotensin-(1–9) in hypertension

I Norambuena-Soto, C Lopez-Crisosto… - Biochemical …, 2022 - Elsevier
Abstract Angiotensin-(1–9)[Ang-(1–9)] is a peptide of the non-canonical renin-angiotensin
system (RAS) synthesized from angiotensin I by the monopeptidase angiotensin-converting …

Recent advances in PTP1B signaling in metabolism and cancer

O Villamar-Cruz, MA Loza-Mejía… - Bioscience …, 2021 - portlandpress.com
Protein tyrosine phosphorylation is one of the major post-translational modifications in
eukaryotic cells and represents a critical regulatory mechanism of a wide variety of signaling …

Mitochondrial dysfunction and the glycolytic switch induced by caveolin-1 phosphorylation promote cancer cell migration, invasion, and metastasis

N Díaz-Valdivia, L Simón, J Díaz, S Martinez-Meza… - Cancers, 2022 - mdpi.com
Simple Summary Caveolin-1 (CAV1) is a membrane protein that has been attributed a dual
role in cancer, acting at early stages as a tumor suppressor and in later stages of the …

Pharmacological activation of potassium channel Kv11. 1 with Ns1643 attenuates triple negative breast cancer cell migration by promoting the dephosphorylation of …

Y Jiang, V Senyuk, K Ma, H Chen, X Qin, S Li, Y Liu… - Cells, 2022 - mdpi.com
The prevention of metastasis is a central goal of cancer therapy. Caveolin-1 (Cav-1) is a
structural membrane and scaffolding protein shown to be a key regulator of late-stage breast …

New insights into prostate Cancer from the renin-angiotensin-aldosterone system.

Y Patel, P Thapa, A Prajapati - Cellular Signalling, 2024 - Elsevier
Prostate cancer is among the most common malignancies found in men, with multifactorial
changes occurring altogether to disrupt the pathophysiology of this gland. The Renin …

Angiotensin-(1–9) prevents vascular remodeling by decreasing vascular smooth muscle cell dedifferentiation through a FoxO1-dependent mechanism

I Norambuena-Soto, MP Ocaranza… - Biochemical …, 2020 - Elsevier
The renin-angiotensin system, one of the main regulators of vascular function, controls
vasoconstriction, inflammation and vascular remodeling. Antagonistic actions of the counter …