Transdifferentiation of epithelial cells into cells with mesenchymal properties and
appearance, that is, epithelial–mesenchymal transition (EMT), is essential during …

The transcription factors nuclear factor-κB (NF-κB) and activating protein-1 (AP-1) are critical
regulators of stress responses, immunity, inflammation and cancer. A large variety of cellular …

Metastasis is the leading cause of cancer-related deaths; metastatic lesions develop from
disseminated cancer cells (DCCs) that can remain dormant. Metastasis-initiating cells are …

Peritoneal fibrosis is characterized by abnormal production of extracellular matrix proteins
leading to progressive thickening of the submesothelial compact zone of the peritoneal …

Peritoneal dialysis (PD) is a renal replacement therapy for patients with end-stage renal
disease that is equivalent to hemodialysis with respect to adequacy, mortality, and other …

NF-κB signaling has been discovered for nearly 40 years. Initially, NF-κB signaling was
identified as a pivotal pathway in mediating inflammatory responses. However, with …

Inflammation can act as a crucial mediator of epithelial-to-mesenchymal transition (EMT). In
this study, we show that oncostatin M (OSM) is expressed in an autocrine/paracrine fashion …

Peritoneal dialysis is a form of renal replacement alternative to the hemodialysis. During this
treatment, the peritoneal membrane acts as a permeable barrier for exchange of solutes and …

The mitogen‐activated protein kinase (MAPK) pathway allows cells to interpret external
signals and respond appropriately, especially during the epithelial‐mesenchymal transition …

Transforming growth factor β (TGFβ) is implicated in human malignancy. Tumors may
escape the tumor suppressor activity of TGFβ by mutating some of its signaling components …