The complement system is an essential component of the innate immune system that
participates in elimination of pathogens and altered host cells and comprises an essential …

Factor H is an essential regulatory protein that plays a critical role in the homeostasis of the
complement system in plasma and in the protection of bystander host cells and tissues from …

Genetic studies into inherited and sporadic hemolytic uremic syndrome. Hemolytic uremic
syndrome (HUS) in adults carries a high morbidity and mortality, and its cause remains …

Several studies have demonstrated genetic predisposition in non–shigatoxin-associated
hemolytic uremic syndrome (HUS), involving regulatory proteins of the complement …

The complement system is an essential player in innate and adaptive immunity. It consists of
three pathways (alternative, classical, and lectin) that initiate either spontaneously …

Factor H (fH), a key alternative complement pathway regulator, is a cofactor for factor I–
mediated cleavage of C3b. fH consists of 20 short consensus repeat (SCR) domains. Sialic …

Summary OTHER ARTICLES PUBLISHED IN THIS TRANSLATIONAL MINI-REVIEW
SERIES ON COMPLEMENT FACTOR H Structural and functional correlations for factor H …

Age related macular degeneration (AMD) is a complex multifactorial disease caused by the
interplay of age and genetic and environmental risk factors. A common feature observed in …

Spirochete bacteria of the Borrelia burgdorferi sensu lato complex cause Lyme borreliosis.
The three pathogenic subspecies Borrelia garinii, Borrelia afzelii, and Borrelia burgdorferi …

The alternative pathway of complement is important in innate immunity, attacking not only
microbes but all unprotected biological surfaces through powerful amplification. It is …