New developments in the biology of fibroblast growth factors
DM Ornitz, N Itoh - WIREs mechanisms of disease, 2022 - Wiley Online Library
The fibroblast growth factor (FGF) family is composed of 18 secreted signaling proteins
consisting of canonical FGFs and endocrine FGFs that activate four receptor tyrosine …
consisting of canonical FGFs and endocrine FGFs that activate four receptor tyrosine …
FGFR families: biological functions and therapeutic interventions in tumors
Q Liu, J Huang, W Yan, Z Liu, S Liu, W Fang - MedComm, 2023 - Wiley Online Library
There are five fibroblast growth factor receptors (FGFRs), namely, FGFR1–FGFR5. When
FGFR binds to its ligand, namely, fibroblast growth factor (FGF), it dimerizes and …
FGFR binds to its ligand, namely, fibroblast growth factor (FGF), it dimerizes and …
[HTML][HTML] Targeting ARF1-IQGAP1 interaction to suppress colorectal cancer metastasis and vemurafenib resistance
HF Hu, GB Gao, X He, YY Li, YJ Li, B Li, YL Pan… - Journal of Advanced …, 2023 - Elsevier
Introduction Acquired resistance to BRAF inhibitor vemurafenib is frequently observed in
metastatic colorectal cancer (CRC), and it is a thorny issue that results in treatment failure …
metastatic colorectal cancer (CRC), and it is a thorny issue that results in treatment failure …
Endometrial organoids derived from Mayer–Rokitansky–Küster–Hauser syndrome patients provide insights into disease-causing pathways
SY Brucker, T Hentrich… - Disease Models & …, 2022 - journals.biologists.com
The uterus is responsible for the nourishment and mechanical protection of the developing
embryo and fetus and is an essential part in mammalian reproduction. Mayer–Rokitansky …
embryo and fetus and is an essential part in mammalian reproduction. Mayer–Rokitansky …
[HTML][HTML] A392V and R945X mutations cause orofacial clefts via impairing PTCH1 function
Q He, X Hao, S Bao, X Wu, L Xu, Y Hou, Y Huang… - Genomics, 2022 - Elsevier
The Hedgehog (HH) signaling plays key roles in embryogenesis and organogenesis, and its
dysfunction causes a variety of human birth defects. Orofacial cleft (OFC) is one of the most …
dysfunction causes a variety of human birth defects. Orofacial cleft (OFC) is one of the most …
[HTML][HTML] Identification of rare loss-of-function variants in FAM3B associated with non-syndromic orofacial clefts
H Zhao, Q He, X Wu, X Liang, Y Jiao, Y Zhang, S Bao… - Genomics, 2023 - Elsevier
Orofacial clefts (OFCs) are the most common congenital craniofacial disorders and cause
serious problems with the appearance, orofacial function and mental health of the patients …
serious problems with the appearance, orofacial function and mental health of the patients …
The role of PANDER and its interplay with IL-6 in the regulation of GLP-1 secretion
Z Li, L Pei, H Xiao, N Chen, F Lai, S Yue… - Endocrine …, 2024 - ec.bioscientifica.com
Glucose-like peptide-1 (GLP-1) is a vital hormone in the intestines that regulates glucose
metabolism. Although pancreatic-derived factor (PANDER) overexpression is known to …
metabolism. Although pancreatic-derived factor (PANDER) overexpression is known to …
Molecular mechanisms of Fam3c cardioprotective activity
A Mura - 2023 - iris.unitn.it
Despite the urgent and broad need to develop new treatments for myocardial infarction (MI)
and heart failure (HF), drug treatment to revert these pathologies has not evolved …
and heart failure (HF), drug treatment to revert these pathologies has not evolved …
Patient-derived endometrial organoids from MRKH patients: Insight in disease causing pathways
SY Brucker, T Hentrich, JM Schulze-Hentrich… - bioRxiv, 2021 - biorxiv.org
The uterus is responsible for the nourishment and mechanical protection of the developing
embryo and fetus and is an essential part in mammalian reproduction. The Mayer …
embryo and fetus and is an essential part in mammalian reproduction. The Mayer …