Hereditary diffuse gastric cancer (HDGC) is an autosomal dominant cancer syndrome that is
characterised by a high prevalence of diffuse gastric cancer and lobular breast cancer. It is …

Like most solid tumours, the microenvironment of epithelial-derived gastric adenocarcinoma
(GAC) consists of a variety of stromal cell types, including fibroblasts, and neuronal …

There exist differences in the epidemiological characteristics, clinicopathological features,
tumor biological characteristics, treatment patterns, and drug selections between gastric …

Patients with chronic atrophic gastritis or intestinal metaplasia (IM) are at risk for gastric
adenocarcinoma. This underscores the importance of diagnosis and risk stratification for …

Gastric adenocarcinoma carries a poor prognosis, in part due to the late stage of diagnosis.
Risk factors include Helicobacter pylori infection, family history of gastric cancer—in …

Almost one million (951 600) new cases of gastric cancer were diagnosed globally in 2012,
resulting in∼ 723 100 deaths [1]. Of these∼ 140 000 cases and∼ 107 000 deaths occurred …

1 ESGE recommends that, where there is a suspicion of eosinophilic esophagitis, at least six
biopsies should be taken, two to four biopsies from the distal esophagus and two to four …

Next-generation sequencing (NGS) technology has expanded in the last decades with
significant improvements in the reliability, sequencing chemistry, pipeline analyses, data …

E-cadherin is a transmembrane glycoprotein which connects epithelial cells together at
adherens junctions. In normal cells, E-cadherin exerts its tumour suppressing role mainly by …

Predictive biomarkers are the mainstay of precision medicine. This review summarizes the
advancements in tissue-based diagnostic biomarkers for gastric cancer, which is considered …