Living species are continuously subjected to all extrinsic forms of reactive oxidants and
others that are produced endogenously. There is extensive literature on the generation and …

Mitochondria are essential for the activity, function and viability of eukaryotic cells and
mitochondrial dysfunction is involved in the pathogenesis of acute kidney injury (AKI) and …

Ovarian aging refers to the process by which ovarian function declines until eventual failure.
The pathogenesis of ovarian aging is complex and diverse; oxidative stress (OS) is …

Mitochondria are best known as the sites for production of respiratory ATP and are essential
for eukaryotic life. They have their own genome but the great majority of the mitochondrial …

Epigenetic regulation of mitochondrial DNA (mtDNA) is an emerging and fast-developing
field of research. Compared to regulation of nucler DNA, mechanisms of mtDNA epigenetic …

Until recently, radiation effects have been considered to be mainly due to nuclear DNA
damage and their management by repair mechanisms. However, molecular biology studies …

Mammalian genes were long thought to be constrained within somatic cells in most cell
types. This concept was challenged recently when cellular organelles including …

Neurodegenerative diseases represent some of the most devastating neurological
disorders, characterized by progressive loss of the structure and function of neurons. Current …

The voltage-dependent anion channel 1 (VDAC1) protein, is an important regulator of
mitochondrial function, and serves as a mitochondrial gatekeeper, with responsibility for …

Sepsis is a dysregulated host response to an infection, characterized by organ failure. The
pathophysiology is complex and incompletely understood, but mitochondria appear to play a …