Chiral tertiary alcohols are an important class of organic compounds which have found wide
applications in both academia and industry. Therefore, various synthetic strategies towards …

A user-friendly approach is presented to sidestep the venerable Grignard addition to
unactivated ketones to access tertiary alcohols by reversing the polarity of the disconnection …

Chiral tertiary alcohols are important building blocks for the synthesis of pharmaceutical
agents and biologically active natural products. The addition of carbon nucleophiles to …

Conjugated ynones are easily accessible feedstock and the existence of an alkyne bond
endows ynones with different attractive reactivities, thus making them unique substrates for …

Allene (C3H4) gas is produced and separated on million-metric-ton scale per year during
petroleum refining but is rarely employed in organic synthesis. Meanwhile, the addition of an …

We report a method for the highly enantioselective CuH-catalyzed allylation of ketones that
employs terminal allenes as allylmetal surrogates. Ketones and allenes bearing diverse and …

The intermolecular radical addition to the carbonyl group is difficult due to the facile
fragmentation of the resulting alkoxyl radical. To date, the intermolecular radical addition to …

A copper-catalyzed three-component coupling of 1, 3-dienes, bis (pinacolato) diboron, and
ketones allows for the chemo-, regio-, diastereo-and enantioselective assembly of densely …

A practical method for enantioselective synthesis of fluoroalkyl-substituted Z-homoallylic
tertiary alcohols has been developed. Reactions may be performed with ketones containing …

We report a dual function asymmetric catalysis by a chiral phosphoric acid catalyst that
controls both enantioselective addition of an achiral α‐vinyl allylboronate to aldehydes and …