Mitochondrial proteins: from biogenesis to functional networks
N Pfanner, B Warscheid, N Wiedemann - Nature reviews Molecular cell …, 2019 - nature.com
Mitochondria are essential for the viability of eukaryotic cells as they perform crucial
functions in bioenergetics, metabolism and signalling and have been associated with …
functions in bioenergetics, metabolism and signalling and have been associated with …
[HTML][HTML] Obesity shapes metabolism in the tumor microenvironment to suppress anti-tumor immunity
Obesity is a major cancer risk factor, but how differences in systemic metabolism change the
tumor microenvironment (TME) and impact anti-tumor immunity is not understood. Here, we …
tumor microenvironment (TME) and impact anti-tumor immunity is not understood. Here, we …
TMTpro-18plex: the expanded and complete set of TMTpro reagents for sample multiplexing
The development of the TMTpro-16plex series expanded the breadth of commercial isobaric
tagging reagents by nearly 50% over classic TMT-11plex. In addition to the described …
tagging reagents by nearly 50% over classic TMT-11plex. In addition to the described …
Excessive cell growth causes cytoplasm dilution and contributes to senescence
Cell size varies greatly between cell types, yet within a specific cell type and growth
condition, cell size is narrowly distributed. Why maintenance of a cell-type specific cell size …
condition, cell size is narrowly distributed. Why maintenance of a cell-type specific cell size …
Targeting immunosuppressive macrophages overcomes PARP inhibitor resistance in BRCA1-associated triple-negative breast cancer
Despite objective responses to poly (ADP-ribose) polymerase (PARP) inhibition and
improvements in progression-free survival (PFS) compared to standard chemotherapy in …
improvements in progression-free survival (PFS) compared to standard chemotherapy in …
TMT labeling for the masses: a robust and cost-efficient, in-solution labeling approach*[S]
J Zecha, S Satpathy, T Kanashova… - Molecular & cellular …, 2019 - ASBMB
Isobaric stable isotope labeling using, for example, tandem mass tags (TMTs) is increasingly
being applied for large-scale proteomic studies. Experiments focusing on proteoform …
being applied for large-scale proteomic studies. Experiments focusing on proteoform …
Optimization of experimental parameters in data-independent mass spectrometry significantly increases depth and reproducibility of results
Comprehensive, reproducible and precise analysis of large sample cohorts is one of the key
objectives of quantitative proteomics. Here, we present an implementation of data …
objectives of quantitative proteomics. Here, we present an implementation of data …
Definition of a high-confidence mitochondrial proteome at quantitative scale
M Morgenstern, SB Stiller, P Lübbert, CD Peikert… - Cell reports, 2017 - cell.com
Mitochondria perform central functions in cellular bioenergetics, metabolism, and signaling,
and their dysfunction has been linked to numerous diseases. The available studies cover …
and their dysfunction has been linked to numerous diseases. The available studies cover …
Mechanism of adrenergic CaV1.2 stimulation revealed by proximity proteomics
G Liu, A Papa, AN Katchman, SI Zakharov, D Roybal… - Nature, 2020 - nature.com
Increased cardiac contractility during the fight-or-flight response is caused by β-adrenergic
augmentation of CaV1. 2 voltage-gated calcium channels,,–. However, this augmentation …
augmentation of CaV1. 2 voltage-gated calcium channels,,–. However, this augmentation …
Emerging mass spectrometry-based proteomics methodologies for novel biomedical applications
LK Pino, J Rose, A O'Broin, S Shah… - Biochemical Society …, 2020 - portlandpress.com
Research into the basic biology of human health and disease, as well as translational
human research and clinical applications, all benefit from the growing accessibility and …
human research and clinical applications, all benefit from the growing accessibility and …