It is almost a century since nisin was discovered in fermented milk cultures, coincidentally in
the same year that penicillin was first described. Over the last 100 years this small, highly …

Antibiotic resistance is mediated through several distinct mechanisms, most of which are
relatively well understood and the clinical importance of which has long been recognized …

The bacterial membrane provides a target for antimicrobial peptides. There are two groups
of bacteria that have characteristically different surface membranes. One is the Gram …

Bacteria encounter a myriad of stresses in their natural environments, including, for
pathogens, their hosts. These stresses elicit a variety of specific and highly regulated …

Our world is now facing a multitude of novel infectious diseases. Bacterial infections are
treated with antibiotics, albeit with increasing difficulty as many of the more common causes …

Genes | Free Full-Text | Two-Component Systems of S. aureus: Signaling and Sensing Mechanisms
Next Article in Journal Genome-Wide Identification, Primary Functional Characterization of the …

Two-component regulatory systems (TCSs) are a major mechanism by which bacteria sense
and respond to changes in their environment. TCSs typically consist of two proteins that …

Bacteriocins are prokaryotic proteins or peptides with antimicrobial activity. Most of them
exhibit a broad spectrum of activity, inhibiting micro-organisms belonging to different genera …

Antimicrobial peptides (AMP) are molecules consisting of 12–100 amino acids synthesized
by certain microbes and released extracellularly to inhibit the growth of other microbes …

Two‐component systems (TCSs) are key regulatory pathways allowing bacteria to adapt
their genetic expression to environmental changes. Bacitracin, a cyclic dodecylpeptide …