The epithelial to mesenchymal transition (EMT) has been proposed to contribute to the
metastatic spread of breast cancer cells. EMT-promoting transcription factors determine a …

Elevated osteoclast (OC) activity is a major contributor to inflammatory bone loss (IBL)
during chronic inflammatory diseases. However, the specific OC precursors (OCPs) …

Steroid‐induced osteoblast apoptosis is a crucial pathological process in steroid‐induced
osteonecrosis of the femoral head (SONFH). Autophagy can resist apoptosis and AMPK …

Rotigotine (RTG) is prescribed as a once-daily transdermal patch for managing early
Parkinson's disease (PD), which presents issues such as skin irritation and poor patient …

Loss of bone is a common medical problem and, while it can be treated with available
therapies, some of these therapies have critical side effects. We have previously …

Intramembranous bone regeneration plays an important role in fixation of intramedullary
implants used in joint replacement and dental implants used in tooth replacement. Despite …

Skeletal stem/progenitor cells (SSPCs) can differentiate into osteogenic or adipogenic
lineage. The mechanism governing lineage allocation of SSPCs is still not completely …

Skeletal growth promoted by endochondral ossification is tightly coordinated by self-renewal
and differentiation of chondrogenic progenitors. Emerging evidence has shown that multiple …

Postmenopausal osteoporosis (PMOP) is a metabolic skeletal disorder characterized by
reduced bone mass and impaired bone microarchitecture resulting in increased bone …

Fibrodysplasia ossificans progressiva (FOP) is a rare congenital disorder characterized by
abnormal bone formation due to ACVR1 gene mutations. The identification of the molecular …