Horizontal gene transfer (HGT) is a major driving force for bacterial evolution. To avoid the
deleterious effects due to the unregulated expression of newly acquired foreign genes …

Supercoiling impacts DNA replication, transcription, protein binding to DNA, and the three-
dimensional organization of chromosomes. However, there are currently no methods to …

Transcription is a noisy and stochastic process that produces sibling‐to‐sibling variations in
physiology across a population of genetically identical cells. This pattern of diversity reflects …

Nucleolar morphology is a well-established indicator of ribosome biogenesis activity that
has served as the foundation of many screens investigating ribosome production. Missing …

DNA in bacterial chromosomes is organized into higher‐order structures by DNA‐binding
proteins called nucleoid‐associated proteins (NAPs) or bacterial chromatin proteins (BCPs) …

Bacterial genomes are folded and organized into compact yet dynamic structures, called
nucleoids. Nucleoid orchestration involves many factors at multiple length scales, such as …

GapR is a nucleoid-associated protein that is an essential regulator of chromosome
replication in the cell cycle model Caulobacter crescentus. Here, we demonstrate that free …

The nucleoid-associated protein GapR found in Caulobacter crescent us is crucial for DNA
replication, transcription, and cell division. Associated with overtwisted DNA in front of …

Here we adapted ATAC-seq to probe chromosome accessibility of bacterial cells. We found
that the chromosome of Caulobacter crescentus is composed of eight differentially …

Our previous work have shown that certain subpopulations of Klebsiella pneumoniae exhibit
significant phenotypic changes under simulated microgravity (SMG), including enhanced …