Creating functional electrical circuits using individual or ensemble molecules, often termed
as “molecular-scale electronics”, not only meets the increasing technical demands of the …

Proteins are major building blocks of life. The protein content of a cell and an organism
provides key information for the understanding of biological processes and disease. Despite …

Direct protein sequencing technologies with improved sensitivity and throughput are still
needed. Here, we propose an alternative method for peptide sequencing based on …

Efforts to sequence single protein molecules in nanopores,,,–have been hampered by the
lack of techniques with sufficient sensitivity to discern the subtle molecular differences …

The implementation of a reliable, rapid, inexpensive, and simple method for whole-proteome
identification would greatly benefit cell biology research and clinical medicine. Proteins are …

Diverse functions of proteins, including synthesis, catalysis, and signaling, result from their
highly variable amino acid sequences. The technology allowing for direct analysis of protein …

The sequencing of single protein molecules using nanopores is faced with a huge challenge
due to the lack of resolution needed to resolve single amino acids. Here we report the direct …

Biotechnological innovations have vastly improved the capacity to perform large-scale
protein studies, while the methods we have for identifying and quantifying individual proteins …

Single-cell profiling methods have had a profound impact on the understanding of cellular
heterogeneity. While genomes and transcriptomes can be explored at the single-cell level …

Scope of the Review. Herein, we provide an up-to-date overview of the field of nanopore
sensing with emphases placed on the advances made in the most recent two years (2014 …