Satellite cells support adult skeletal muscle fiber adaptations to loading in numerous ways.
The fusion of satellite cells, driven by cell‐autonomous and/or extrinsic factors, contributes …

Skeletal muscle hypertrophy can be induced by hormones and growth factors acting directly
as positive regulators of muscle growth or indirectly by neutralizing negative regulators, and …

While the majority of cells contain a single nucleus, cell types such as trophoblasts,
osteoclasts, and skeletal myofibers require multinucleation. One advantage of …

The maintenance of skeletal muscle mass plays a critical role in health and quality of life.
One of the most potent regulators of skeletal muscle mass is mechanical loading, and …

Mammalian cells exhibit remarkable diversity in cell size, but the factors that regulate
establishment and maintenance of these sizes remain poorly understood. This is especially …

The question whether the muscle hypertrophy induced by resistance training, hormone
administration or genetic manipulation is accompanied by a proportional increase in muscle …

Muscle fibers are the largest cells in the body, and one of its few syncytia. Individual cell
sizes are variable and adaptable, but what governs cell size has been unclear. We find that …

Skeletal muscle memory is an exciting phenomenon gaining significant traction across
several scientific communities, among exercise practitioners, and the public. Research has …

Multinuclear muscle fibers are the most voluminous cells in skeletal muscle and the primary
drivers of growth in response to loading. Outside the muscle fiber, however, is a diversity of …

Satellite cells are required for postnatal development, skeletal muscle regeneration across
the lifespan, and skeletal muscle hypertrophy prior to maturity. Our group has aimed to …