The complex challenge of antenatal steroid therapy nonresponsiveness

T Takahashi, AH Jobe, EL Fee, JP Newnham… - American journal of …, 2022 - Elsevier
Antenatal steroid therapy is standard care for women at imminent risk of preterm delivery.
When deliveries occur within 7 days of treatment, antenatal steroid therapy reduces the risk …

Antenatal steroids elicited neurodegenerative-associated transcriptional changes in the hippocampus of preterm fetal sheep independent of lung maturation

SWD Carter, EL Fee, H Usuda, G Oguz, A Ramasamy… - BMC medicine, 2024 - Springer
Background Antenatal steroid therapy for fetal lung maturation is routinely administered to
women at risk of preterm delivery. There is strong evidence to demonstrate benefit from …

Betamethasone phosphate reduces the efficacy of antenatal steroid therapy and is associated with lower birthweights when administered to pregnant sheep in …

T Takahashi, EL Fee, Y Takahashi, M Saito… - American journal of …, 2022 - Elsevier
Background Antenatal corticosteroid therapy is a standard of care for women at imminent
risk of preterm labor. However, the optimal (maximum benefit and minimal risk of side …

[HTML][HTML] Low-dose antenatal betamethasone treatment achieves preterm lung maturation equivalent to that of the World Health Organization dexamethasone regimen …

H Usuda, EL Fee, S Carter, L Furfaro… - American Journal of …, 2022 - Elsevier
Background The intramuscular administration of antenatal steroids to women at risk of
preterm delivery achieves high maternal and fetal plasma steroid concentrations, which are …

Chapter for antenatal steroids–Treatment drift for a potent therapy with unknown long-term safety seminars in fetal and neonatal medicine

AH Jobe, AF Schmidt - Seminars in Fetal and Neonatal Medicine, 2021 - Elsevier
This chapter on therapeutic drift with antenatal steroids will make the case that this pilar of
treatment to improve the outcomes of preterm infants, despite multiple Randomized Control …

Antenatal corticosteroids: an updated assessment of anticipated benefits and potential risks

AH Jobe, RL Goldenberg, MW Kemp - American Journal of Obstetrics and …, 2024 - Elsevier
Antenatal steroid therapy is increasingly central to the obstetrical management of women at
imminent risk of preterm birth. For women likely to deliver between 24 and 34 weeks' …

Molecular mechanisms regulating lysophosphatidylcholine acyltransferase 1 (LPCAT1) in human pregnancy

N Purandare, P Minchella, M Somayajulu, KJ Kramer… - Placenta, 2021 - Elsevier
Abstract Introduction Lysophosphatidylcholine Acyltransferase 1 (LPCAT1) is necessary for
surfactant production in fetal lungs. Mechanisms responsible for its regulation during …

One percent of the clinical dose used for antenatal steroid therapy is sufficient to induce lung maturation when administered directly to the preterm ovine fetus

EL Fee, T Takahashi, Y Takahashi… - … of Physiology-Lung …, 2022 - journals.physiology.org
Antenatal steroids (ANSs) are routinely administered to women judged to be at imminent risk
of preterm delivery. Their principal benefit is precocious functional maturation of the preterm …

Continuous but not pulsed low-dose fetal betamethasone exposures extend the durability of antenatal steroid therapy

T Takahashi, Y Takahashi, EL Fee… - … of Physiology-Lung …, 2022 - journals.physiology.org
Antenatal steroid (ANS) therapy is the standard care for women at imminent risk of preterm
labor. Despite extensive and long-standing use, 40%–50% of babies exposed antenatally to …

Use, misuse, and overuse of antenatal corticosteroids. A retrospective cohort study

L Cojocaru, S Chakravarthy, H Tadbiri… - Journal of Perinatal …, 2023 - degruyter.com
Objectives To evaluate the timing of antenatal corticosteroids (ACS) administration in
relation to the delivery timing based on indications and risk factors for preterm delivery …