UDP-glycosyltransferases (UGTs) catalyze the covalent addition of sugars to a broad range
of lipophilic molecules. This biotransformation plays a critical role in elimination of a broad …

The NNRTI efavirenz has long been one of the most frequently employed antiretroviral drugs
in the multidrug regimens used to treat HIV infection, in accordance with its well …

The HIV type‐1 nonnucleoside reverse transcriptase inhibitor, efavirenz, is widely used to
treat HIV type‐1 infection. Efavirenz is predominantly metabolized into inactive metabolites …

Advances in solid drug nanoparticle technologies have resulted in a number of long-acting
(LA) formulations with the potential for once monthly or longer administration. Such …

Atovaquone is used as a fixed-dose combination with proguanil (Malarone) for treating
children and adults with uncomplicated malaria or as chemoprophylaxis for preventing …

Glucuronidation is an important metabolic pathway for many small endogenous and
exogenous lipophilic compounds, including bilirubin, steroid hormones, bile acids …

Objectives We evaluated the importance of ethnicity and pharmacogenetic variations in
determining efavirenz pharmacokinetics, auto-induction and immunological outcomes in two …

The human uridine diphospho (UDP)-glucuronosyltransferase (UGT) superfamily comprises
enzymes responsible for a major biotransformation phase II pathway: the glucuronidation …

Introduction: Efavirenz commonly causes early neuropsychiatric side effects, but tolerance
develops in most patients. There is emerging evidence that efavirenz use may damage …

Highly active antiretroviral therapy (HAART) has substantially reduced morbidity and
mortality of AIDS-related complications in patients with HIV; however, the prevalence of …