The COVID misinfodemic: not new, never more lethal

C Apetrei, PA Marx, JW Mellors, I Pandrea - Trends in Microbiology, 2022 - cell.com
'Infodemia'is a portmanteau between 'information'and 'epidemics', referring to wide and rapid
accumulation and dissemination of information, misinformation, and disinformation about a …

Interferon-γ and infectious diseases: Lessons and prospects

JL Casanova, JD MacMicking, CF Nathan - Science, 2024 - science.org
Infectious diseases continue to claim many lives. Prevention of morbidity and mortality from
these diseases would benefit not just from new medicines and vaccines but also from a …

[HTML][HTML] Bat pluripotent stem cells reveal unusual entanglement between host and viruses

M Déjosez, A Marin, GM Hughes, AE Morales… - Cell, 2023 - cell.com
Bats are distinctive among mammals due to their ability to fly, use laryngeal echolocation,
and tolerate viruses. However, there are currently no reliable cellular models for studying bat …

Bat species assemblage predicts coronavirus prevalence

M Meyer, DW Melville, HJ Baldwin, K Wilhelm… - Nature …, 2024 - nature.com
Anthropogenic disturbances and the subsequent loss of biodiversity are altering species
abundances and communities. Since species vary in their pathogen competence, spatio …

Single-cell transcriptome analysis of the in vivo response to viral infection in the cave nectar bat Eonycteris spelaea

AM Gamage, WOY Chan, F Zhu, YT Lim, S Long… - Immunity, 2022 - cell.com
Bats are reservoir hosts of many zoonotic viruses with pandemic potential. We utilized single-
cell transcriptome sequencing (scRNA-seq) to analyze the immune response in bat lungs …

Comparative analyses of bat genomes identify distinct evolution of immunity in Old World fruit bats

S Tian, J Zeng, H Jiao, D Zhang, L Zhang, C Lei… - Science …, 2023 - science.org
Bats have been identified as natural reservoir hosts of several zoonotic viruses, prompting
suggestions that they have unique immunological adaptations. Among bats, Old World fruit …

Antiviral effects of interferon-stimulated genes in bats

D Zhang, AT Irving - Frontiers in Cellular and Infection Microbiology, 2023 - frontiersin.org
The interferon pathway is the first line of defense in viral infection in all mammals, and its
induction stimulates broad expression of interferon-stimulated genes (ISGs). In mice and …

[HTML][HTML] Comparison of antiviral responses in two bat species reveals conserved and divergent innate immune pathways

L Schneor, S Kaltenbach, S Friedman, D Tussia-Cohen… - iScience, 2023 - cell.com
Bats host a range of disease-causing viruses without displaying clinical symptoms. The
mechanisms behind this are a continuous source of interest. Here, we studied the antiviral …

Lifespan extension in long-lived vertebrates rooted in ecological adaptation

O Omotoso, VN Gladyshev, X Zhou - Frontiers in Cell and …, 2021 - frontiersin.org
Contemporary studies on aging and longevity have largely overlooked the role that
adaptation plays in lifespan variation across species. Emerging evidence indicates that the …

MHC class II genes mediate susceptibility and resistance to coronavirus infections in bats

DW Schmid, M Meyer, K Wilhelm, T Tilley… - Molecular …, 2023 - Wiley Online Library
Understanding the immunogenetic basis of coronavirus (CoV) susceptibility in major
pathogen reservoirs, such as bats, is central to inferring their zoonotic potential. Members of …