Peroxisomes contain numerous enzymatic activities that are important for mammalian
physiology. Patients lacking either all peroxisomal functions or a single enzyme or …

D-Amino acid oxidase (DAAO) is an FAD-containing flavoenzyme that catalyzes with
absolute stereoselectivity the oxidative deamination of all natural D-amino acids, the only …

NMDA receptors (NMDARs) require the coagonists d-serine or glycine for their activation,
but whether the identity of the coagonist could be synapse specific and developmentally …

L-serine is a nonessential amino acid in eukaryotic cells, used for protein synthesis and in
producing phosphoglycerides, glycerides, sphingolipids, phosphatidylserine, and …

Schizophrenia is a severe mental illness that affects~ 1% of the world's population. It is
clinically characterized by positive, negative, and cognitive symptoms. Currently available …

Abstract The N‐Methyl D‐Aspartic acid (NMDA) receptors (NMDAR) are key tetrameric
ionotropic glutamate receptors that transduce glutamatergic signals throughout the central …

L-serine generated in astrocytes plays a pivotal role in modulating essential neurometabolic
processes, while its enantiomer, D-serine, specifically regulates NMDA receptor (NMDAR) …

Accumulating evidence during the last decade established that d-serine is a key signaling
molecule utilized by neurons and astroglia in the mammalian central nervous system. d …

Fear, anxiety, and trauma-related disorders, including post-traumatic stress disorder (PTSD),
are quite common and debilitating, with an estimated lifetime prevalence of~ 28% in …

The potential implication of a decrease in the function of N-methyl-d-aspartate receptors
(NMDARs) in the pathophysiology of schizophrenia has long been hypothesised …