Two-metal-ion catalysis: Inhibition of DNA polymerase activity by a third divalent metal ion
J Wang, WH Konigsberg - Frontiers in Molecular Biosciences, 2022 - frontiersin.org
Almost all DNA polymerases (pols) exhibit bell-shaped activity curves as a function of both
pH and Mg2+ concentration. The pol activity is reduced when the pH deviates from the …
pH and Mg2+ concentration. The pol activity is reduced when the pH deviates from the …
Kinetic mechanism of DNA polymerases: contributions of conformational dynamics and a third divalent metal ion
Faithful transmission and maintenance of genetic material is primarily fulfilled by DNA
polymerases. During DNA replication, these enzymes catalyze incorporation of …
polymerases. During DNA replication, these enzymes catalyze incorporation of …
Elucidating molecular interactions of L-nucleotides with HIV-1 reverse transcriptase and mechanism of M184V-caused drug resistance
M Hung, EJ Tokarsky, L Lagpacan, L Zhang… - Communications …, 2019 - nature.com
Abstract Emtricitabine (FTC) and lamivudine (3TC), containing an oxathiolane ring with
unnatural (−)-stereochemistry, are widely used nucleoside reverse transcriptase inhibitors …
unnatural (−)-stereochemistry, are widely used nucleoside reverse transcriptase inhibitors …
Structural insights into the recognition of nucleoside reverse transcriptase inhibitors by HIV‐1 reverse transcriptase: First crystal structures with reverse transcriptase …
N Bertoletti, AH Chan, RF Schinazi, YW Yin… - Protein …, 2019 - Wiley Online Library
The retrovirus HIV‐1 has been a major health issue since its discovery in the early 80s. In
2017, over 37 million people were infected with HIV‐1, of which 1.8 million were new …
2017, over 37 million people were infected with HIV‐1, of which 1.8 million were new …
Structural basis of HIV inhibition by L-nucleosides: Opportunities for drug development and repurposing
FX Ruiz, A Hoang, CR Dilmore, JJ DeStefano… - Drug discovery today, 2022 - Elsevier
Highlights•L-NRTI-TP drugs bind RT/nucleic acid in a non-productive conformation for
chemistry.•Binding affinity is similar to D stereoisomers but incorporation rate is very slow.•L …
chemistry.•Binding affinity is similar to D stereoisomers but incorporation rate is very slow.•L …
[HTML][HTML] In crystallo observation of active site dynamics and transient metal ion binding within DNA polymerases
C Chang, G Zhou, Y Gao - Structural Dynamics, 2023 - pubs.aip.org
DNA polymerases are the enzymatic catalysts that synthesize DNA during DNA replication
and repair. Kinetic studies and x-ray crystallography have uncovered the overall kinetic …
and repair. Kinetic studies and x-ray crystallography have uncovered the overall kinetic …
Mechanistic Studies of DNA Replication, Lesion Bypass, and Editing
AT Raper - 2018 - rave.ohiolink.edu
DNA acts as a molecular blueprint for life. Adenosine, cytidine, guanosine, and thymidine
nucleotides serve as the building blocks of DNA and can be arranged in near-endless …
nucleotides serve as the building blocks of DNA and can be arranged in near-endless …
A Structural and Biochemical Investigation of Human DNA Polymerase Beta
AJ Reed - 2018 - rave.ohiolink.edu
Adenosine, guanosine, cytidine, and thymidine nucleotides are the building blocks of life
and are arranged in distinct combinations to give unique genomic DNA sequences. These …
and are arranged in distinct combinations to give unique genomic DNA sequences. These …
Investigating Current Mechanistic Models of DNA Replication and Repair
PC Wallenmeyer - 2017 - rave.ohiolink.edu
DNA polymerases (pols) play a pivotal role in both the replication and the repair of genomic
DNA. Replicative pols are highly accurate and processive, synthesizing long stretches of …
DNA. Replicative pols are highly accurate and processive, synthesizing long stretches of …